| — | Amazing Stories: The Movie II | John Walters (archive footage) |
| — | Jimpa | Jimpa |
| — | The Rule of Jenny Pen | |
| 2024 | Cabrini | Mayor Gould |
| 2024 | Conclave | Cardinal Tremblay |
| 2024 | Spellbound | Minister Bolinar (voice) |
| 2024 | Art Happens Here with John Lithgow | Self |
| 2023 | Killers of the Flower Moon | Prosecutor Peter Leaward |
| 2023 | Sharper | Richard Hobbes |
| 2023 | Dick Van Dyke: 98 Years of Magic | Self |
| 2023 | Liv Ullmann: A Road Less Travelled | Self |
| 2022 | The Bubble | Tom the Studio Chairman |
| 2022 | The Old Man | Harold Harper |
| 2022 | Sherri | Self - Guest |
| 2022 | Chez Bob | |
| 2021 | Dexter: New Blood | Arthur Mitchell |
| 2021 | Ultra City Smiths | Ol' Gregory Timms |
| 2021 | Live in Front of a Studio Audience: The Facts of Life and Diff'rent Strokes | Philip Drummond |
| 2021 | Myths and Hymns | |
| 2021 | Emily @ the Edge of Chaos | Sir Isaac Newton (voice) |
| 2020 | Perry Mason | Elias Birchard 'E.B.' Jonathan |
| 2020 | Disclosure | Self (archive footage) |
| 2020 | Give My Regards to Broadway | Self |
| 2020 | Stars in the House | Self - Special Guest |
| 2019 | Pet Sematary | Jud Crandall |
| 2019 | Bombshell | Roger Ailes |
| 2019 | Late Night | Walter Lovell |
| 2019 | The Tomorrow Man | Ed Hemsler |
| 2019 | The Kelly Clarkson Show | Self |
| 2019 | The Investigation: A Search for the Truth in Ten Acts | President Donald J. Trump |
| 2019 | On Broadway | Self |
| 2018 | James Cameron's Story of Science Fiction | Self |
| 2018 | Mister Rogers: It's You I Like | Self |
| 2018 | The Great Celebrity Bake Off for Stand Up To Cancer | Self - Guest |
| 2018 | Pet Sematary: The Tale of Timmy Baterman | Jud Crandall |
| 2018 | Firing Line with Margaret Hoover | |
| 2017 | Pitch Perfect 3 | Fergus |
| 2017 | Daddy's Home 2 | Don |
| 2017 | Beatriz at Dinner | Doug Strutt |
| 2017 | Trial & Error | Larry Henderson |
| 2017 | The Pulitzer At 100 | Self |
| 2017 | Broadway: The Next Generation | Self |
| 2017 | They All Saw a Cat | |
| 2017 | Hickory Dickory Doc | Himself |
| 2016 | The Accountant | Lamar Blackburn |
| 2016 | The Crown | Winston Churchill |
| 2016 | Miss Sloane | Senator Ronald Sperling |
| 2016 | Shakespeare Live! From the RSC | Self - Performer |
| 2016 | Ode to Joy: Beethoven's Symphony No. 9 | Narrator |
| 2015 | The Late Show with Stephen Colbert | Self - Guest |
| 2015 | The Late Show with Stephen Colbert | |
| 2015 | The Late Show with Stephen Colbert | Self |
| 2015 | Best of Enemies | Self |
| 2015 | Close Up with The Hollywood Reporter | Self |
| 2015 | Inside 'Interstellar' | Self |
| 2015 | Projections of America | Self - Narrator (voice) |
| 2015 | Lord John | |
| 2014 | Interstellar | Donald |
| 2014 | The Homesman | Reverend Alfred Dowd |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | The Tonight Show Starring Jimmy Fallon | |
| 2014 | Love Is Strange | Ben |
| 2014 | Late Night with Seth Meyers | Self |
| 2014 | 9 Kisses | Man in Club |
| 2014 | The Roosevelts: An Intimate History | James Roosevelt (voice) |
| 2014 | Les As de la Jungle 2 : Le Trésor du Vieux Jim | Maurice (voice) |
| 2014 | Variety Studio: Actors on Actors | Self |
| 2013 | Once Upon a Time in Wonderland | The White Rabbit (voice) |
| 2013 | Shrek Stories | Lord Farquaad (voice) |
| 2013 | Marvin Hamlisch: What He Did For Love | Himself |
| 2013 | Timms Valley | Ol' Gregory Timms |
| 2013 | National Theatre Live: The Magistrate | Posket |
| 2012 | This Is 40 | Oliver |
| 2012 | The Campaign | Glen Motch |
| 2012 | Casting By | Self |
| 2012 | Finding Your Roots | Self |
| 2011 | Rise of the Planet of the Apes | Charles Rodman |
| 2011 | New Year's Eve | Jonathan Cox (uncredited) |
| 2011 | Prohibition | Reader / H.L. Mencken (voice) |
| 2011 | Shrek: Once Upon a Time | Self |
| 2010 | Leap Year | Jack Brady |
| 2010 | Conan | Self |
| 2009 | Confessions of a Shopaholic | Edgar West |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2009 | The Macabre World of Lavender Williams | God |
| 2009 | Miracle in a Box: A Piano Reborn | Narrator |
| 2008 | Car of the Future | Narrator |
| 2007 | The Graham Norton Show | Self |
| 2007 | ShowBusiness: The Road to Broadway | Self |
| 2006 | Dexter | Arthur Mitchell |
| 2006 | Dreamgirls | Jerry Harris |
| 2006 | 30 Rock | John Lithgow |
| 2006 | Twenty Good Years | |
| 2006 | Sangre | Cafe chef and owner |
| 2006 | The Great Robot Race: The DARPA Grand Challenge | Narrator |
| 2006 | The Best of The Tony Awards: The Plays | René Gallimard (segment "M. Butterfly") |
| 2005 | How I Met Your Mother | Jerry Whittaker |
| 2005 | The Colbert Report | |
| 2005 | Einstein's Big Idea | Narrator (voice) U.S. edition |
| 2005 | The Apprentice: Martha Stewart | |
| 2004 | Kinsey | Alfred Seguine Kinsey |
| 2004 | The Ghost of Lord Farquaad | Ghost of Farquaad (voice) |
| 2004 | The Life and Death of Peter Sellers | Blake Edwards |
| 2004 | The Tony Danza Show | Self |
| 2004 | Dogs and More Dogs | Narrator |
| 2003 | VH1 Goes Inside | |
| 2003 | Bark, George | |
| 2002 | Orange County | Bud Brumder |
| 2002 | E! Live from the Red Carpet | Self |
| 2002 | Buckaroo Banzai Declassified | Self |
| 2001 | Shrek | Lord Farquaad (voice) |
| 2001 | Shrek in the Swamp Karaoke Dance Party | Lord Farquaad (singing voice) |
| 2000 | Rugrats in Paris: The Movie | Jean-Claude (voice) |
| 2000 | Don Quixote | Don Quixote de La Mancha / Alonso Quixano |
| 2000 | 95 Worlds and Counting | Narrator |
| 1999 | The Early Show | Self |
| 1999 | Tales from the Crypt: The Robert Zemeckis Collection | Dr. Oscar Charles |
| 1998 | A Civil Action | Judge Walter J. Skinner |
| 1998 | Homegrown | Malcolm / Robert Stockman |
| 1998 | Johnny Skidmarks | Sergeant Larry Skovik |
| 1997 | The View | Self |
| 1997 | The View | Self - Guest |
| 1997 | Officer Buckle and Gloria | Narrator (voice) |
| 1996 | The Daily Show | Self |
| 1996 | 3rd Rock from the Sun | Dick Solomon |
| 1996 | Hollow Point | Thomas Livingston |
| 1996 | Cosby | John Lithgow |
| 1996 | The West | Self |
| 1996 | The West | Self / Uriah Oblinger (voice) |
| 1996 | The Rosie O'Donnell Show | Self - Guest |
| 1996 | Special Effects: Anything Can Happen | Narrator |
| 1995 | The Tuskegee Airmen | Senator Conyers |
| 1995 | Redwood Curtain | Laird Riordan |
| 1995 | My Brother's Keeper | Tom Bradley / Bob Bradley |
| 1995 | American Cinema | Narrator |
| 1994 | Silent Fall | Dr. Rene Harlinger |
| 1994 | A Good Man in Africa | Arthur Fanshawe, British High Commissioner |
| 1994 | Princess Caraboo | Professor Wilkinson |
| 1994 | World War II: When Lions Roared | Franklin Delano Roosevelt |
| 1994 | American Cinema | |
| 1993 | Cliffhanger | Eric Qualen |
| 1993 | The Pelican Brief | Smith Keen |
| 1993 | Frasier | Madman Martinez (voice) |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1993 | The Wrong Man | Phillip Mills |
| 1993 | Love, Cheat & Steal | Paul Harrington |
| 1993 | Sylvester and the Magic Pebble | Narrator |
| 1993 | The Country Mouse & the City Mouse: A Christmas Tale | Alexander (voice) |
| 1992 | Raising Cain | Carter Nix / Cain / Dr. Nix / Josh / Margo |
| 1991 | Ricochet | Earl Talbott Blake |
| 1991 | At Play in the Fields of the Lord | Leslie Huben |
| 1991 | The Boys | |
| 1990 | Memphis Belle | Bruce Derringer |
| 1990 | Ivory Hunters | Robert Carter |
| 1990 | Night of 100 Stars III | Self |
| 1990 | John Lithgow's Kid-Sized Concert | |
| 1989 | The Simpsons | Gus (voice) |
| 1989 | The Simpsons | John Lithgow (voice) |
| 1989 | Tales from the Crypt | Dr. Oscar Charles |
| 1989 | Out Cold | Dave |
| 1989 | Traveling Man | Ben Cluett |
| 1988 | Distant Thunder | Mark Lambert |
| 1987 | Harry and the Hendersons | George Henderson |
| 1987 | Baby Girl Scott | Neil Scott |
| 1987 | The Amazing Bone | Narrator |
| 1986 | The Manhattan Project | John Mathewson |
| 1986 | Resting Place | Maj. Kendall Laird |
| 1985 | Santa Claus: The Movie | B.Z. |
| 1985 | Amazing Stories | John Walters |
| 1985 | Mesmerized | Oliver Thompson |
| 1985 | Santa Claus: The Making of the Movie | Self |
| 1984 | Footloose | Rev. Shaw Moore |
| 1984 | 2010 | Dr. Walter Curnow |
| 1984 | The Adventures of Buckaroo Banzai Across the 8th Dimension | Lord John Whorfin |
| 1984 | The Glitter Dome | Sgt. Marty Wellborn |
| 1984 | Goldilocks and the Three Bears | Goldilocks' Father |
| 1983 | Terms of Endearment | Sam Burns |
| 1983 | Twilight Zone: The Movie | Valentine |
| 1983 | The Day After | Joe Huxley |
| 1982 | The World According to Garp | Roberta Muldoon |
| 1982 | Faerie Tale Theatre | Goldilocks' Father |
| 1982 | I'm Dancing as Fast as I Can | Mr. Brunner |
| 1982 | Not in Front of the Children | Richard Carruthers |
| 1981 | Blow Out | Burke |
| 1980 | Big Blonde | Herbie Morse |
| 1980 | The Oldest Living Graduate | Clarence |
| 1980 | Mom, the Wolfman and Me | Wally |
| 1979 | All That Jazz | Lucas Sergeant |
| 1979 | Rich Kids | Paul Philips |
| 1978 | The Big Fix | Sam Sebastian |
| 1977 | Secret Service | Capt. Thorne |
| 1976 | Obsession | Robert Lasalle |
| 1975 | Saturday Night Live | Self - Host |
| 1974 | NOVA | Narrator |
| 1974 | The Country Girl | Paul Unger |
| 1972 | Dealing: Or the Berkeley-to-Boston Forty-Brick Lost-Bag Blues | John |
| 1971 | Great Performances | Capt. Thorne |
| 1956 | Tony Awards | Self - Presenter |
| 1956 | Tony Awards | Self - Nominee & Performer |
| 1956 | Tony Awards | Self - Winner |
| 1952 | Today | Self |
| 1951 | Hallmark Hall of Fame | Paul Unger |
| 1951 | Hallmark Hall of Fame | Major Kendall Laird |
| 1951 | Hallmark Hall of Fame | Laird Riordan |
