| — | Anansi Boys | Bird Woman |
| — | Pierre the Pigeon-Hawk | |
| — | Sister Act 3 | Deloris |
| — | Fairy Tale Forest: Flower of the Dawn | Storyteller (voice) |
| — | Leopardi & Co | Mildred |
| 2025 | Naya: Legend of the Golden Dolphin | Aqua (voice) |
| 2024 | Atrabilious | Dr. Andrea Hart |
| 2024 | Super/Man: The Christopher Reeve Story | Self |
| 2023 | Three Trees | (Narration) |
| 2022 | Music Is My Life - Joseph Shabalala and Ladysmith Black Mambazo | Self |
| 2016 | Do I Look Like a Lady? (Comedians and Singers) | Self (archive footage) |
| 2010 | New York Street Games | Self |
| — | Saturday TV Funhouse | Iceberg (voice) |
| 2024 | Babes | Dawn's Breasts |
| 2024 | Ezra | Jayne |
| 2024 | Outlaw Posse | Stagecoach Mary |
| 2024 | Butterfly in the Sky | Self |
| 2024 | I'm "George Lucas": A Connor Ratliff Story | Self (archive footage) |
| 2023 | The Color Purple | Midwife (uncredited) |
| 2023 | Barry Humphries at the BBC | Self (archive material) |
| 2023 | Oprah & The Color Purple Journey | Self |
| 2023 | Our Barbara -- A Special Edition of 20/20 | Self |
| 2022 | Luck | Captain (voice) |
| 2022 | Till | Alma |
| 2022 | My Father's Dragon | Cat (voice) |
| 2022 | Is That Black Enough for You?!? | Self |
| 2022 | JANET JACKSON. | Self |
| 2022 | Cuomo | Self - Guest |
| 2022 | Cinderella: The Reunion, A Special Edition of 20/20 | Self |
| 2022 | 20/20 Presents Black Panther: In Search of Wakanda | Self |
| 2022 | Sherri | Self - Guest |
| 2022 | Soul of a Nation Presents: Screen Queens Rising | Self |
| 2022 | Whoopi Goldberg: The Winning Act | Self (archive footage) |
| 2022 | Tony Bennett: Forget Me Not | Self |
| 2022 | Bill Cosby: Walking Free | Self (archive footage) |
| 2021 | Marvel's M.O.D.O.K. | Marian Pouncy / Poundcakes (voice) |
| 2021 | JFK Revisited: Through the Looking Glass | Narrator (voice) |
| 2021 | The Center Seat: 55 Years of Star Trek | Self |
| 2021 | Rita Moreno: Just a Girl Who Decided to Go for It | Self |
| 2021 | JFK: Destiny Betrayed | Self - Narrator (voice) |
| 2021 | The Most Magical Story on Earth: 50 Years of Walt Disney World | Self - Host |
| 2021 | The Story of Late Night | Self |
| 2021 | Sesame Street: 50 Years Of Sunny Days | Self - Guest |
| 2020 | Star Trek: Picard | Guinan |
| 2020 | The Stand | Abagail "Mother Abagail" Freemantle |
| 2020 | Staged | Mary |
| 2020 | Chadwick Boseman: A Tribute for a King | Self - Co-host, "The View" |
| 2020 | Sarah Cooper: Everything's Fine | Whoopi Goldberg (voice) |
| 2020 | My Darling Vivian | Self (archive footage) |
| 2020 | The Paley Center Salutes Law & Order: SVU | (archive footage) |
| 2020 | Feeding America Comedy Festival | Self |
| 2020 | The Sit-In: Harry Belafonte Hosts The Tonight Show | Self |
| 2020 | Siempre, Luis | Self (archive footage) |
| 2020 | Billy Connolly: It’s Been a Pleasure... | Self |
| 2020 | The Con | Narrator (voice) |
| 2020 | The Great Work Begins: Scenes from Angels in America | Whoopi Goldberg |
| 2020 | Find Your Groove | Self |
| 2020 | Walter Winchell: The Power of Gossip | Narrator |
| 2019 | Godfather of Harlem | Miss Willa |
| 2019 | Amphibia | Mother Olm (voice) |
| 2019 | Scooby-Doo and Guess Who? | Whoopi Goldberg (voice) |
| 2019 | The Kelly Clarkson Show | Self |
| 2019 | Lorena | Herself |
| 2019 | Cracked Up | Self |
| 2019 | Tamron Hall | Self - Guest |
| 2019 | Desus & Mero | Self |
| 2019 | Sesame Street's 50th Anniversary Celebration | Self |
| 2019 | Charley Pride: I'm Just Me | Self |
| 2019 | The Most Magnificent Thing | Narrator (voice) |
| 2018 | Nobody's Fool | Lola |
| 2018 | Furlough | Moms |
| 2018 | James Cameron's Story of Science Fiction | Self |
| 2018 | Scotty and the Secret History of Hollywood | Self (archive footage) |
| 2018 | Summer Camp Island | Barb (voice) |
| 2018 | The Gospel According to André | Self |
| 2018 | Mister Rogers: It's You I Like | Self |
| 2018 | The Shop | Self |
| 2018 | Random Acts of Flyness | Police Officer |
| 2018 | Trump @War | Self (archive footage) |
| 2018 | Citizen Rose | Self |
| 2018 | Olympia | Herself |
| 2018 | The Rolling Stones - Voodoo Lounge Uncut | Self - Host |
| 2018 | Basketball: A Love Story | Self (archive footage) |
| 2017 | Descendants 2 | Ursula (voice) (uncredited) |
| 2017 | 9/11 | Metzie |
| 2017 | Gilbert | Self |
| 2017 | The Problem with Apu | Self |
| 2017 | A Very Sordid Wedding | Abernatha Coleman |
| 2017 | The Nineties | Self (archive footage) |
| 2017 | The Truth Is in the Stars | Self |
| 2017 | Decorating Disney: Holiday Magic | Host |
| 2017 | Yamasong: March of the Hollows | Yari |
| 2017 | King of the Dancehall | Loretta Brixton |
| 2017 | Sammy Davis, Jr.: I've Gotta Be Me | Self |
| 2016 | The Beatles: Eight Days a Week - The Touring Years | Self |
| 2016 | The Tick | Whoopi Goldberg |
| 2016 | X-Rated 2: The Greatest Adult Stars of All-Time | Herself |
| 2016 | Floyd Norman: An Animated Life | Herself |
| 2016 | 50 Years of Star Trek | Self |
| 2016 | Ask the Storybots | |
| 2015 | The Late Show with Stephen Colbert | Self |
| 2015 | Misery Loves Comedy | Self |
| 2015 | StarTalk with Neil deGrasse Tyson | Self |
| 2015 | Black Dog, Red Dog | Calliope |
| 2015 | The Three Stooges: Hey Moe! Hey Dad! | Self |
| 2015 | De magie van het dagboek van Anne Frank | Self |
| 2014 | Teenage Mutant Ninja Turtles | Bernadette Thompson |
| 2014 | BoJack Horseman | Mikhaela (voice) |
| 2014 | Top Five | Self |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | The Tonight Show Starring Jimmy Fallon | |
| 2014 | Broad City | Self |
| 2014 | Late Night with Seth Meyers | Self |
| 2014 | Big Stone Gap | Fleeta Mullins |
| 2014 | A Day Late and a Dollar Short | Viola |
| 2014 | The 7D | Magic Mirror (voice) |
| 2014 | Robin Williams Remembered | Self |
| 2013 | Blackfish | Self |
| 2013 | Once Upon a Time in Wonderland | Mrs. Rabbit (voice) |
| 2013 | Richard Pryor: Omit the Logic | Self |
| 2013 | Star Trek: The Next Generation - The Best of Both Worlds | Guinan (archive footage) |
| 2013 | Moms Mabley | Self |
| 2013 | Why We Laugh: Funny Women | Self |
| 2013 | Kelly Clarkson's Cautionary Christmas Music Tale | Self |
| 2013 | Miracle Rising: South Africa | Self |
| 2013 | The Contradictions of Fair Hope | Narrator |
| 2012 | Katy Perry: Part of Me | Self |
| 2012 | Paul Simon: Under African Skies | Self |
| 2012 | 12-12-12 | The Concert for Sandy Relief | Self |
| 2012 | Radioman | Self |
| 2011 | The Muppets | Whoopi Goldberg |
| 2011 | A Little Bit of Heaven | God |
| 2011 | Being Elmo: A Puppeteer's Journey | Narrator (voice) |
| 2011 | Bubble Guppies | Pirate Myra (voice) |
| 2011 | The Little Engine That Could | The Tower (voice) |
| 2010 | Toy Story 3 | Stretch (voice) |
| 2010 | Blue Bloods | Regina Thomas |
| 2010 | For Colored Girls | Alice / White |
| 2010 | RuPaul's Drag Race: Untucked | Self - Guest |
| 2010 | Teenage Paparazzo | Self |
| 2010 | See You in September | Lindsay's Therapist (uncredited) |
| 2010 | 2Everything2Terrible2: Tokyo Drift | archival footage |
| 2010 | The Black List: Volume Three | Self |
| 2009 | Glee | Carmen Tibideaux |
| 2009 | The Middle | Jane Marsh |
| 2009 | RuPaul's Drag Race | Self - Judge |
| 2009 | RuPaul's Drag Race | Self - Special Guest |
| 2009 | Madea Goes to Jail | Self |
| 2009 | Late Night with Jimmy Fallon | Self |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2009 | कमबख़्त इश्क़ | Whoopi Goldberg |
| 2009 | Star Trek: The Captains' Summit | Self |
| 2009 | The Justin Lee Collins Show | Self - Guest |
| 2009 | Journey to the Stars | Narrator (voice) |
| 2009 | Square Roots: The Story of SpongeBob SquarePants | Herself |
| 2009 | Stream | Jodi Quinn |
| 2009 | Van Der Vorst Ziet Sterren | |
| 2008 | Snow Buddies | Miss Mittens (voice) |
| 2008 | A Muppets Christmas: Letters to Santa | Taxi Driver |
| 2008 | Descendants | Red Flower (voice) |
| 2008 | Meerkat Manor: The Story Begins | Self - Narrator (voice) |
| 2008 | Shatner's Raw Nerve | Self |
| 2007 | The Graham Norton Show | Self |
| 2007 | Annie Leibovitz: Life Through a Lens | Self |
| 2007 | Mr. Warmth: The Don Rickles Project | Self |
| 2007 | If I Had Known I Was a Genius | Mom |
| 2007 | The Naked Brothers Band | Herself |
| 2007 | Elton 60: Live At Madison Square Garden | Self |
| 2007 | Ghost Stories: The Making of a Classic | Self |
| 2007 | The Sophisticated Misfit | Herself |
| 2007 | The Word According to Whoopi | Herself |
| 2006 | 30 Rock | Whoopi Goldberg |
| 2006 | Everyone's Hero | Darlin' (voice) |
| 2006 | Doogal | Ermintrude (voice) |
| 2006 | Rachael Ray | |
| 2006 | Farce of the Penguins | Helen (voice) |
| 2006 | The One Show | Self - Guest |
| 2006 | Homie Spumoni | Thelma |
| 2006 | The N Word | Herself |
| 2006 | So NoTORIous | |
| 2006 | Comic Relief 2006 | |
| 2005 | Everybody Hates Chris | |
| 2005 | Racing Stripes | Franny (voice) |
| 2005 | Hell's Kitchen | Self - Restaurant Patron |
| 2005 | The Aristocrats | Self |
| 2005 | Jiminy Glick in Lalawood | Whoopi Goldberg |
| 2005 | Kathy Griffin: My Life on the D-List | Self |
| 2005 | The Reichen Show | Self |
| 2005 | Whoopi Goldberg: Back to Broadway | Herself / Fontaine / Lurleen / Crippled Lady |
| 2004 | The Lion King 1½ | Shenzi (voice) |
| 2004 | Pinocchio 3000 | Cyberina (voice) |
| 2004 | Superbabies: Baby Geniuses 2 | Whoopi Goldberg |
| 2004 | The Tony Danza Show | Self - Guest |
| 2004 | TV in Black: The First Fifty Years | Self (archive footage) |
| 2004 | Whoopi's Littleburg | |
| 2004 | Uta Hagen's Acting Class | Self |
| 2004 | The World of Nat King Cole | Self |
| 2003 | Real Time with Bill Maher | Self |
| 2003 | The Ellen DeGeneres Show | Self |
| 2003 | Jimmy Kimmel Live! | |
| 2003 | It's a Very Merry Muppet Christmas Movie | Daniel's 'Boss' |
| 2003 | Pauly Shore Is Dead | Whoopi Goldberg |
| 2003 | Blizzard | Blizzard (voice) |
| 2003 | Good Fences | Mabel Spader |
| 2003 | Unchained Memories: Readings from the Slave Narratives | Narrator (voice) |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self |
| 2003 | New Jersey Devils Stanley Cup 2002-2003 Champions | Voice |
| 2003 | Whoopi | Mavis Rae |
| 2003 | Declaration of Independence | Self |
| 2002 | Star Trek: Nemesis | Guinan (uncredited) |
| 2002 | Liberty's Kids | |
| 2002 | Searching for Debra Winger | Self |
| 2002 | Showboy | Herself |
| 2002 | Madeline: My Fair Madeline | Miss Clavel (voice) |
| 2002 | Dawn French's Girls Who Do Comedy | |
| 2001 | Rat Race | Vera Baker |
| 2001 | Law & Order: Criminal Intent | Chesley Watkins |
| 2001 | Monkeybone | Death |
| 2001 | Call Me Claus | Lucy Cullins |
| 2001 | Kingdom Come | Raynelle Slocumb |
| 2001 | What Makes a Family | Terry Harrison |
| 2001 | The Hollywood Sign | Woman at Funeral (uncredited) |
| 2001 | Ghost: Remembering the Magic | Self |
| 2001 | Golden Dreams | Califia, the Queen of California |
| 2001 | The Making of 'A Charlie Brown Christmas' | Self - Hostess |
| 2001 | Rescued from the Closet | Self |
| 2000 | The Adventures of Rocky & Bullwinkle | Judge Cameo (uncredited) |
| 2000 | Strong Medicine | Dr. Lydia Emerson |
| 2000 | More Dogs Than Bones | Cléo |
| 2000 | Chuck Jones: Extremes and In-Betweens - A Life in Animation | Self |
| 2000 | The Weber Show | Whoopi Goldberg |
| 2000 | Here's to You, Charlie Brown: 50 Great Years | Self - Host |
| 2000 | Mary Pickford: A Life on Film | Self - Host / Narrator |
| 1999 | Law & Order: Special Victims Unit | Janette Grayson |
| 1999 | Girl, Interrupted | Valerie |
| 1999 | The Deep End of the Ocean | Candy Bliss |
| 1999 | Alice in Wonderland | Cheshire Cat |
| 1999 | The Magical Legend of the Leprechauns | The Grand Banshee |
| 1999 | Get Bruce! | Self |
| 1999 | Our Friend, Martin | Mrs. Peck (voice) |
| 1999 | Billy Connolly: Erect for 30 Years | |
| 1999 | Alegría: An Enchanting Fable | Baby Clown |
| 1999 | Jackie's Back! | Nurse Ethyl Washington Rue Owens (Jackie's Sister) |
| 1999 | The Foxbusters | Ransome (voice) |
| 1998 | The Rugrats Movie | Ranger Margaret (voice) |
| 1998 | Celebrity Deathmatch | |
| 1998 | Whose Line Is It Anyway? | Herself |
| 1998 | Rudolph the Red-Nosed Reindeer: The Movie | Stormella (voice) |
| 1998 | How Stella Got Her Groove Back | Delilah Abraham |
| 1998 | A Knight in Camelot | Dr. Vivien Morgan |
| 1998 | An Alan Smithee Film: Burn, Hollywood, Burn | Whoopi Goldberg |
| 1998 | 成龍的傳奇 | Self |
| 1998 | AFI's 100 Years... 100 Movies | Self |
| 1998 | Hollywood Squares | Self - Panelist |
| 1998 | Hollywood Squares | Self |
| 1998 | Titey | The Iceberg (voice) |
| 1998 | Junket Whore | Self |
| 1997 | In & Out | Whoopi Goldberg (uncredited) |
| 1997 | Cinderella | Queen Constantina |
| 1997 | The View | Self - Moderator |
| 1997 | The View | Self - Co-Host |
| 1997 | Bear in the Big Blue House | Edwina Badger (voice) |
| 1997 | A Christmas Carol | Spirit of Christmas Present (voice) |
| 1997 | In the Gloaming | Nurse Myrna |
| 1997 | Pitch | Herself |
| 1997 | Destination Anywhere | Cabbie |
| 1997 | The Chris Rock Show | |
| 1997 | Classic Albums | Self (archive footage) |
| 1997 | Mother Goose: A Rappin' and Rhymin' Special | Mother Gooseberg (voice) |
| 1997 | Sports on the Silver Screen | Self (archive footage) |
| 1997 | Happy Birthday Elizabeth: A Celebration of Life | Self |
| 1996 | Bordello of Blood | Hospital Patient (uncredited) |
| 1996 | Bogus | Harriet Franklin |
| 1996 | The Associate | Laurel Ayres |
| 1996 | Eddie | Eddie Franklin |
| 1996 | Ghosts of Mississippi | Myrlie Evers |
| 1996 | The Celluloid Closet | Self |
| 1996 | Muppets Tonight | Self |
| 1996 | The Sunshine Boys | Nurse (uncredited) |
| 1996 | The Rosie O'Donnell Show | Self - Guest |
| 1996 | The Good, The Bad, and the Beautiful | Self (archive footage) |
| 1995 | Boys on the Side | Jane Deluca |
| 1995 | MADtv | Self |
| 1995 | Theodore Rex | Katie Coltrane |
| 1995 | Moonlight and Valentino | Sylvie Morrow |
| 1995 | Happily Ever After: Fairy Tales for Every Child | Zenobia (voice) |
| 1995 | Happily Ever After: Fairy Tales for Every Child | Mother Gooseberg (voice) |
| 1995 | Star Trek: The Next Generation - Time's Arrow | Guinan (archive footage) |
| 1995 | The Rolling Stones: Voodoo Lounge | Self - Hostess |
| 1994 | The Lion King | Shenzi (voice) |
| 1994 | Star Trek: Generations | Guinan (uncredited) |
| 1994 | The Little Rascals | Buckwheat's Mom |
| 1994 | The Pagemaster | Fantasy (voice) |
| 1994 | Corrina, Corrina | Corrina Washington |
| 1994 | Inside the Actors Studio | Self |
| 1994 | Liberation | Narrator |
| 1994 | Sesame Street: The Best of Elmo | Self |
| 1994 | But... Seriously | Self (archive footage) |
| 1994 | The Making of 'The Pagemaster' | Self (archive footage) |
| 1993 | Sister Act 2: Back in the Habit | Deloris Van Cartier |
| 1993 | The Nanny | Whoopi Goldberg |
| 1993 | The Nanny | Edna |
| 1993 | National Lampoon's Loaded Weapon 1 | Billy York (uncredited) |
| 1993 | Made in America | Sarah Mathews |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1993 | Naked in New York | Tragedy Mask on Theater Wall |
| 1993 | A Cool Like That Christmas | Mom / Irwin (voice) |
| 1993 | Aretha Franklin: Duets | Self |
| 1992 | Sister Act | Deloris Van Cartier / Sister Mary Clarence |
| 1992 | The Player | Detective Avery |
| 1992 | The Tonight Show with Jay Leno | |
| 1992 | Sarafina! | Mary Masembuko |
| 1992 | The Magical World of Chuck Jones | Self |
| 1992 | Defenders of Dynatron City | Ms. Megawatt (voice) |
| 1992 | Wisecracks | |
| 1991 | Soapdish | Rose Schwartz |
| 1991 | House Party 2 | Professor (uncredited) |
| 1991 | Star Trek: 25th Anniversary Special | Self |
| 1991 | Star Trek: The Next Generation - Redemption | Guinan (archive footage) |
| 1991 | Chez Whoopi | Self - Host |
| 1990 | Ghost | Oda Mae Brown |
| 1990 | Captain Planet and the Planeteers | Gaia (voice) |
| 1990 | The Long Walk Home | Odessa Cotter |
| 1990 | Bagdad Cafe | |
| 1990 | Celebrity Guide to Wine | Self |
| 1990 | Red Hot + Blue: A Tribute to Cole Porter | Self (uncredited) |
| 1989 | Tales from the Crypt | Peligre |
| 1989 | Homer and Eddie | Eddie Cervi |
| 1989 | Hanna-Barbera's 50th | Self |
| 1989 | Kiss Shot | Sarah Collins |
| 1989 | Beverly Hills Brats | Self |
| 1989 | Whoopi Goldberg Presents Billy Connolly | Herself |
| 1989 | Comic Relief III | |
| 1988 | Clara's Heart | Clara Mayfield |
| 1988 | Pee-wee's Playhouse Christmas Special | Self |
| 1988 | The Telephone | Vashti Blue |
| 1988 | This Morning | Self |
| 1988 | Whoopi Goldberg's Fontaine... Why Am I Straight? | Fontaine |
| 1988 | Free to Be... a Family | Self |
| 1988 | The Nelson Mandela 70th Birthday Concert | Self |
| 1987 | Star Trek: The Next Generation | Guinan |
| 1987 | Burglar | Bernice 'Bernie' Rhodenbarr |
| 1987 | Fatal Beauty | Rita Rizzoli |
| 1987 | A Different World | Dr. Jordan |
| 1987 | Citizen Steve | Self - Actress |
| 1987 | Happy 100th Birthday, Hollywood | Self |
| 1987 | Carol, Carl, Whoopi and Robin | |
| 1987 | Scared Straight!: 10 Years Later | Self - Host |
| 1987 | The Pointer Sisters: Up All Nite | Self |
| 1987 | Funny, You Don't Look 200: A Constitutional Vaudeville | Lu Lu - Constitutional Caterer |
| 1986 | Jumpin' Jack Flash | Terry Dolittle |
| 1986 | Pee-wee's Playhouse | |
| 1986 | American Masters | Self |
| 1986 | The Making of Captain EO | Host |
| 1986 | Doctor Duck's Super Secret All-Purpose Sauce | Self |
| 1986 | Bob Goldthwait -- Don't Watch This Show | |
| 1986 | Comic Relief | Self - Host |
| 1985 | The Color Purple | Celie |
| 1985 | Moonlighting | Camille Brand |
| 1985 | Whoopi Goldberg: Direct from Broadway | Self |
| 1985 | Night of 100 Stars II | Self |
| 1984 | Muppet Babies | |
| 1984 | CBS Schoolbreak Special | Mariah Johnston |
| 1982 | Wogan | Self |
| 1982 | Citizen | |
| 1981 | Wetten, dass..? | Self |
| 1981 | De TV Show | Self |
| 1975 | Saturday Night Live | Self - Cameo (uncredited) |
| 1973 | The American Film Institute Salute to ... | Self |
| 1971 | Great Performances | Self |
| 1956 | Tony Awards | Self - Presenter |
| 1956 | Tony Awards | Self - Host |
| 1953 | The Oscars | Self |
