| — | Saurus City | Slade Klossus (voice) |
| — | Stranglehold | |
| — | Dirty | Murray |
| — | Out Late | Angelo |
| — | Auxiliary Man | Maury Goldman |
| 2024 | Scream Before You Die | Governor Starks |
| 2024 | Joe Baby | Prentice Stanton |
| — | The Making of 'The Last Winter' | Self |
| — | Cottonmouth | Victor Cain |
| — | Carrier | Eli Pierson |
| 2024 | The Instigators | Mayor Miccelli |
| 2024 | మిస్టర్ అండ్ మిసెస్ స్మిత్ | Toby Hellinger |
| 2024 | Day of the Fight | |
| 2024 | Succubus | Dr. Orion Zephyr |
| 2024 | Thug | |
| 2023 | Transformers: Rise of the Beasts | Optimus Primal (voice) |
| 2023 | Poker Face | Sterling Frost Sr. |
| 2023 | Poker Face | Sterling Frost Sr. (voice) |
| 2023 | Adventure Time: Fionna & Cake | Lich (voice) |
| 2023 | The Retirement Plan | Bobo |
| 2023 | The Baker | Pappi |
| 2023 | Heroes of the Golden Masks | Kunyi (voice) |
| 2022 | Guillermo del Toro's Pinocchio | Podesta (voice) |
| 2022 | There Are No Saints | Sans |
| 2022 | The Last Victim | Sheriff Hickey |
| 2022 | American Badass: A Michael Madsen Retrospective | Self |
| 2022 | شيابني هني | The Merc |
| 2021 | Don't Look Up | Benedict Drask |
| 2021 | Nightmare Alley | Bruno |
| 2021 | This Game's Called Murder | Mr. Wallendorf |
| 2021 | Boris Karloff: The Man Behind the Monster | Self |
| 2021 | The Innocent Butler | Self |
| 2020 | Monster Hunter | Admiral |
| 2020 | Adventure Time: Distant Lands | The Lich (voice) |
| 2020 | The Big Ugly | Preston |
| 2020 | Clover | Mr. Wiley |
| 2020 | A Place Among the Dead | RP |
| 2019 | The Capture | Frank Napier |
| 2019 | Hell on the Border | Charlie Storm |
| 2019 | The Great War | General Pershing |
| 2019 | Reprisal | Big Graham |
| 2019 | Run with the Hunted | Birdie |
| 2019 | Go Fish | Bernardo (voice) |
| 2019 | Havana Kyrie | Henry |
| 2019 | Westside vs the World | Narrator |
| 2018 | Asher | Asher |
| 2018 | After the Screaming Stops | Self |
| 2018 | The Escape of Prisoner 614 | The Sheriff |
| 2018 | Sergio & Serguéi | Peter |
| 2018 | Transformers: Power of the Primes | Optimus Primal / Optimal Optimus (voice) |
| 2018 | The Steam Engines of Oz | Magnus (voice) |
| 2017 | Chuck | Al Braverman |
| 2017 | Pottersville | Sheriff Jack |
| 2017 | Howard Lovecraft & the Undersea Kingdom | Shoggoth (voice) |
| 2017 | Prison Fighters: Five Rounds to Freedom | Narrator |
| 2016 | Fantastic Beasts and Where to Find Them | Gnarlak |
| 2016 | Trollhunters: Tales of Arcadia | Bular (voice) |
| 2016 | StartUp | Wes Chandler |
| 2016 | Howard Lovecraft & the Frozen Kingdom | Shoggoth (voice) |
| 2015 | Moonwalkers | Kidman |
| 2015 | Stonewall | Ed Murphy |
| 2014 | The Book of Life | Xibalba (voice) |
| 2014 | 13 Sins | Det. Chilcoat |
| 2014 | Skin Trade | Viktor Dragovic |
| 2014 | Poker Night | Calabrese |
| 2014 | Kid Cannabis | Barry Lerner |
| 2014 | Before I Disappear | Bill |
| 2014 | Hand of God | Judge Pernell Harris |
| 2014 | Lost Soul: The Doomed Journey of Richard Stanley's “Island of Dr. Moreau” | Self (archive footage) |
| 2014 | The Virginian | Judge Henry South |
| 2014 | Desiree | Anslinger |
| 2014 | Tbilisi, I Love You | |
| 2014 | Nfinity Champions League Cheerleading Event | Narrator (voice) |
| 2014 | Savage Mutts | Terry 'Shotgun' Coburn |
| 2013 | Pacific Rim | Hannibal Chau |
| 2013 | Percy Jackson: Sea of Monsters | Polyphemus (voice) |
| 2013 | The Blacklist | Luther Braxton |
| 2013 | Justice League: The Flashpoint Paradox | Slade Wilson / Deathstroke (voice) |
| 2013 | Crave | Pete |
| 2013 | Turbo FAST | Darryl (voice) |
| 2013 | The Frame | Hannibal Chau |
| 2013 | Forget Us Not | Narrator |
| 2012 | Bad Ass | Mayor Williams |
| 2012 | The Scorpion King 3: Battle for Redemption | Horus |
| 2012 | The Punisher: Dirty Laundry | Big Mike |
| 2012 | 3, 2, 1... Frankie Go Boom | Phyllis |
| 2011 | Drive | Nino |
| 2011 | Season of the Witch | Felson |
| 2011 | Conan the Barbarian | Corin |
| 2011 | Green Lantern: The Animated Series | Sinestro (voice) |
| 2011 | The Littlest Angel | God |
| 2010 | Tangled | Stabbington Brother (voice) |
| 2010 | Bunraku | Nicola |
| 2010 | The Legend of Secret Pass | Parker (voice) |
| 2010 | Killer by Nature | Dr. Julian |
| 2010 | Dark Metropolis | |
| 2010 | Acts of Violence | Priest Bill |
| 2009 | Archer | Ramon Limon (voice) |
| 2009 | 1000 Ways to Die | Self - Narrator (voice) |
| 2009 | The Devil's Tomb | Wesley |
| 2009 | Dark Country | Sheriff |
| 2009 | The Job | Jim |
| 2008 | Hellboy II: The Golden Army | Hellboy |
| 2008 | Sons of Anarchy | Clay Morrow |
| 2008 | The Spiderwick Chronicles | Red Cap (voice) (uncredited) |
| 2008 | Star Wars: The Clone Wars | Gha Nachkt (voice) |
| 2008 | Outlander | Gunnar |
| 2008 | Mutant Chronicles | Brother Samuel |
| 2008 | Batman: The Brave and the Bold | Double X / Dr. Ecks (voice) |
| 2008 | I Sell the Dead | Father Duffy |
| 2008 | Local Color | Curtis Sunday |
| 2008 | Hellboy: In Service of the Demon | Self |
| 2008 | Uncross the Stars | Bobby |
| 2008 | Starz Inside: Comic Books Unbound | Self - Hellboy, Hellboy 1 & 2 |
| 2007 | In the Name of the King: A Dungeon Siege Tale | Norick |
| 2007 | Battle for Terra | Elder Vorin (voice) |
| 2007 | Afro Samurai | Justice (voice) |
| 2007 | Hellboy Animated: Blood and Iron | Hellboy (voice) |
| 2007 | 5ive Girls | Father Drake |
| 2007 | Hellboy Animated: Iron Shoes | Hellboy (voice) |
| 2007 | No. 6 | The Man in the Hat |
| 2006 | Scooby-Doo! Pirates Ahoy! | Captain Skunkbeard / Biff Wellington (voice) |
| 2006 | The Last Winter | Ed Pollack |
| 2006 | Desperation | Collie Entragian |
| 2006 | Hellboy Animated: Sword of Storms | Hellboy (voice) |
| 2006 | Pro-Life | Dwayne Burcell |
| 2006 | How to Go Out on a Date in Queens | Vito |
| 2006 | Working with a Master: Mick Garris | |
| 2005 | American Dad! | Monster Hunter (voice) |
| 2005 | American Dad! | Colonel (voice) |
| 2005 | American Dad! | Fang (voice) |
| 2005 | American Dad! | Bandit (voice) |
| 2005 | Tarzan II | Kago (voice) |
| 2005 | Scooby-Doo! in Where's My Mummy? | Hotep / Ancient One #2 (voice) |
| 2005 | Masters of Horror | |
| 2005 | What's New, Scooby-Doo? Vol. 5: Sports Spooktacular | (voice) |
| 2005 | Missing in America | Red |
| 2005 | Второй фронт | General von Binding |
| 2004 | Hellboy | Hellboy |
| 2004 | Danny Phantom | Vice Principal Lancer (voice) |
| 2004 | Justice League Unlimited | Orion (voice) |
| 2004 | The Batman | Rumor / Killer Croc (voice) |
| 2004 | The Batman | Killer Croc (voice) |
| 2004 | On Air with Ryan Seacrest | Self |
| 2004 | 100 Scariest Movie Moments | Self |
| 2004 | Hellboy: The Seeds of Creation | Self |
| 2004 | Quiet Kill | Detective Sergeant Perry |
| 2003 | Looney Tunes: Back in Action | Acme VP, Never Learning |
| 2003 | Teen Titans | Slade (voice) |
| 2003 | Absolon | Murchison |
| 2003 | Rats | Dr. William Winslow |
| 2003 | One Step Beyond: The Making of Alien Resurrection | Self |
| 2003 | Two Soldiers | Colonel McKellog |
| 2003 | Boys on the Run | Captain |
| 2003 | Hoodlum & Son | 'Ugly' Jim McCrae |
| 2002 | Blade II | Reinhardt |
| 2002 | Star Trek: Nemesis | The Reman Viceroy |
| 2002 | What's New, Scooby-Doo? | Inspector Malpumpkin / Joe / Frozen Fiend (voice) |
| 2002 | Kim Possible | Warhawk (voice) |
| 2002 | Shakedown | Christopher Bellows |
| 2001 | Enemy at the Gates | Koulikov |
| 2001 | Justice League | Orion (voice) |
| 2001 | Justice League | Clayface / Matt Hagen (voice) |
| 2001 | Down | Mitchell |
| 2001 | The Tick | Fiery Blaze |
| 2001 | The Legend of Tarzan | Colonel Nikolas Rokoff (voice) |
| 2001 | Night Class | Morgan |
| 2000 | Titan A.E. | Prof. Sam Tucker (voice) |
| 2000 | Jackie Chan Adventures | Karl Nivor (voice) |
| 2000 | Static Shock | Heavyman / Koenig (voice) |
| 2000 | Bread and Roses | Party Guest (uncredited) |
| 2000 | Buzz Lightyear of Star Command | Leader (voice) |
| 2000 | Price of Glory | Nick Everson |
| 2000 | The King's Guard | Lord Morton |
| 2000 | The Trial of Old Drum | Charles Burden Sr. |
| 2000 | Operation Sandman | Dr. Harlan Jessup |
| 1999 | Happy, Texas | Marshal Nalhober |
| 1999 | Primal Force | Frank Brodie |
| 1999 | Family Law | |
| 1999 | Supreme Sanction | The Director |
| 1999 | The Big Guy and Rusty the Boy Robot | |
| 1998 | Charmed | Mr. Kellman |
| 1998 | The Wild Thornberrys | Wild Horse (voice) |
| 1998 | An American Tail: The Treasure of Manhattan Island | Grasping (voice) |
| 1998 | I Woke Up Early the Day I Died | Cemetery Caretaker |
| 1998 | The Magnificent Seven | Josiah Sanchez |
| 1998 | Houdini | Booking Agent |
| 1998 | A Town Has Turned to Dust | Jerry Paul |
| 1998 | Frogs for Snakes | Gascone |
| 1997 | Alien Resurrection | Johner |
| 1997 | The New Batman Adventures | Clayface (voice) |
| 1997 | The View | Self |
| 1997 | Prince Valiant | Boltar |
| 1997 | The Second Civil War | Alan Manieski |
| 1997 | Perversions of Science | 40132 |
| 1997 | The Protector | Dr. Ramsey Krago |
| 1997 | Tinseltown | Cliff |
| 1997 | The Second Civil War | Alan Manieski |
| 1997 | Betty | Donnie Shank |
| 1996 | Hey Arnold! | Mickey Kaline (voice) |
| 1996 | Hey Arnold! | Mickey Kaline / Weiner Cooker (voice) |
| 1996 | The Island of Dr. Moreau | Sayer of the Law |
| 1996 | Superman: The Animated Series | Jax-Ur (voice) |
| 1996 | Mortal Kombat: Defenders of the Realm | Kurtis Stryker (voice) |
| 1996 | Animaniacs: Spooky Stuff | Satan (voice) |
| 1996 | Tracey Takes On... | |
| 1995 | La Cité des Enfants Perdus | One |
| 1995 | The Last Supper | Norman Arbuthnot |
| 1995 | Fluke | Sylvester |
| 1995 | The Outer Limits | Lt. Col. Brandon Grace |
| 1995 | Tiny Toon Night Ghoulery | Mr. Scratch (voice) |
| 1995 | Mr. Stitch | Doctor Frederick Texarian |
| 1995 | The Adventures of Captain Zoom in Outer Space | Lord Vox of Vestron |
| 1995 | Original Sins | Chas Bradley |
| 1995 | Lightning | Gambler |
| 1994 | Police Academy: Mission to Moscow | Konstantine Konali |
| 1994 | Aladdin | |
| 1994 | Aladdin | Arbutus (voice) |
| 1994 | Iron Man | Hulk (voice) |
| 1994 | Fantastic Four | |
| 1994 | When the Bough Breaks | Dr. Douglas Eben |
| 1994 | The Cisco Kid | Lt. Col. Delacroix |
| 1994 | Sensation | Detective Pantella |
| 1994 | Double Exposure | John McClure |
| 1994 | Phantom 2040: The Ghost Who Walks | Graft |
| 1993 | Animaniacs | Satan (voice) |
| 1993 | Cronos | Angel de la Guardia |
| 1993 | The Adventures of Huck Finn | Pap Finn |
| 1993 | Romeo Is Bleeding | Jack's Attorney |
| 1993 | Bonkers | Sgt. Grating (voice) |
| 1992 | Batman: The Animated Series | Driller (voice) |
| 1992 | Batman: The Animated Series | Clayface (voice) |
| 1992 | The Little Mermaid | Apollo (voice) |
| 1992 | Sleepwalkers | Captain Soames |
| 1992 | Highlander: The Series | The Messenger |
| 1992 | Blind Man's Bluff | Frank Cerrillo |
| 1991 | The Legend of Prince Valiant | |
| 1988 | A Stoning in Fulham County | Jacob Shuler |
| 1987 | Beauty and the Beast | Vincent |
| 1987 | La rosa dei nomi | Self |
| 1986 | The Name of the Rose | Salvatore |
| 1986 | Die Abtei des Verbrechens - Umberto Ecos „Der Name der Rose“ wird verfilmt | Self (uncredited) |
| 1985 | MacGruder and Loud | Attorney |
| 1984 | Miami Vice | |
| 1984 | The Ice Pirates | Zeno |
| 1981 | La Guerre du feu | Amoukar |
| 1981 | The Fall Guy | |
