| — | Mythos | |
| — | Behind the Labels | Narrator (voice) |
| — | Red Bird Lane | |
| — | Still of Night | |
| — | Pitchfork | |
| — | Bad Moms' Moms | Isis |
| — | Tunnels | |
| — | Butterfly in the Typewriter | Thelma Toole |
| — | Materia Viva | self |
| — | Exit Right | Jan Randall |
| 2024 | Super/Man: The Christopher Reeve Story | Self |
| 2024 | The Gutter | Linda Curson |
| 2024 | The Six Triple Eight | |
| 2024 | Rebel Nun | |
| 2022 | Byron Bowers: Spiritual N***a | Self (uncredited) |
| 2015 | Enzian: When the Lights Go Up | Self (archive footage) |
| 2013 | Trailblazers in Habits | Narrator (voice) |
| 2002 | The Next Industrial Revolution | Narrator (voice) |
| 2002 | Facing Arthur | Narrator (voice) |
| 2001 | The Shaman's Apprentice | Narrator (voice) |
| 1999 | The Secret Life of Geisha | Narrator (voice) |
| 1996 | Father Roy: Inside the School of Assassins | Narrator (voice) |
| 1996 | Clive Anderson All Talk | Self |
| 1995 | One Woman, One Vote | Narrator (voice) |
| 1994 | School of the Americas Assassins | Narrator (voice) |
| 1974 | The Satan Murders | Kate |
| 1974 | June Moon | Eileen |
| 1972 | The Rimers of Eldritch | Patsy Johnson |
| 1970 | A World Apart | Patrice Kahlman |
| — | Nonnas | |
| 2024 | The Fabulous Four | Lou |
| 2024 | Gracie & Pedro: Pets to the Rescue! | Shades (voice) |
| 2024 | De "Matrix" à "Sense8", la révolution Wachowski | Self (archive footage) |
| 2023 | ப்ளூ பீட்டில் | Victoria Kord |
| 2023 | Maybe I Do | Monica |
| 2023 | Pretty Baby: Brooke Shields | Self (archive footage) |
| 2023 | Krapopolis | Demeter (voice) |
| 2023 | Healing US | Narrator |
| 2022 | Monarch | Dottie Cantrell Roman |
| 2022 | Forty Winks | Connie Montoya |
| 2021 | Jolt | Woman with No Name |
| 2021 | Ride the Eagle | Honey |
| 2021 | Rocky Horror 45: The Movie | Self |
| 2021 | Cher: In Her Own Words | Self (archive footage) (uncredited) |
| 2020 | Fearless | Mom (voice) |
| 2020 | VHYes | Tracy Beth |
| 2020 | LOVE | The Art Teacher |
| 2019 | The Death & Life of John F. Donovan | Grace Donovan |
| 2019 | Blackbird | Lily |
| 2019 | The Jesus Rolls | Jean |
| 2019 | Roger Vivier's Jewels to Shoes | Drama Teacher |
| 2018 | Survivor's Guide to Prison | Narrator (voice) |
| 2018 | Viper Club | Helen |
| 2018 | Neo Yokio: Pink Christmas | Aunt Agitha |
| 2017 | A Bad Moms Christmas | Isis Dunkler |
| 2017 | FEUD | Bette Davis |
| 2017 | Neo Yokio | Aunt Agatha (voice) |
| 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self |
| 2016 | Zoolander 2 | Susan Sarandon (uncredited) |
| 2016 | 3 Generations | Dolly |
| 2016 | The Meddler | Marnie Minervini |
| 2016 | Mothers and Daughters | Millie |
| 2016 | Search Party | Lylah |
| 2016 | Chelsea | Self |
| 2016 | Spark: A Space Tail | Bananny (voice) |
| 2016 | My Entire High School Sinking Into the Sea | Lunch Lady Lorraine (voice) |
| 2016 | Ace the Case: Manhattan Mystery | Detective Dottie Wheel |
| 2015 | Hell & Back | Barb the Angel (voice) |
| 2015 | The Late Late Show with James Corden | Self |
| 2015 | Moonbeam City | Warden (voice) |
| 2015 | Unity | Narrator (voice) |
| 2015 | The Secret Life of Marilyn Monroe | Gladys Mortenson |
| 2015 | StarTalk with Neil deGrasse Tyson | Self |
| 2014 | Tammy | Pearl |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest |
| 2014 | The Calling | Hazel Micallef |
| 2014 | Ping Pong Summer | Randi Jammer |
| 2014 | Doll & Em | Susan |
| 2014 | We Are Many | Self |
| 2014 | The Past Is a Grotesque Animal | Self |
| 2013 | Rick and Morty | Dr. Helen Wong (voice) |
| 2013 | Snitch | Joanne Keeghan |
| 2013 | The Big Wedding | Beatrice 'Bebe' McBride |
| 2013 | Ray Donovan | Samantha Winslow |
| 2013 | The Last of Robin Hood | Florence Aadland |
| 2013 | Greenwich Village: Music That Defined a Generation | Suze Rotolo (voice) |
| 2013 | Irwin & Fran | Narrator |
| 2013 | The Frame | Sarah Roberts |
| 2012 | Cloud Atlas | Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess |
| 2012 | That's My Boy | Mary McGarricle (Present Day) |
| 2012 | Robot & Frank | Jennifer |
| 2012 | Arbitrage | Ellen Miller |
| 2012 | The Company You Keep | Sharon Solarz |
| 2012 | How to Make Money Selling Drugs | Self |
| 2012 | 12-12-12 | The Concert for Sandy Relief | Self |
| 2012 | Nothing Like Chocolate | Narrator (voice) |
| 2011 | Jeff, Who Lives at Home | Sharon Thompkins |
| 2011 | Fight for Your Right Revisited | Mother |
| 2011 | Islamic Art: Mirror of the Invisible World | Narrator (voice) |
| 2011 | Hamish and Andy's Gap Year | Self |
| 2010 | Wall Street: Money Never Sleeps | Sylvia Moore |
| 2010 | You Don't Know Jack | Janet Good |
| 2010 | Mike & Molly | J.C. Small |
| 2010 | Peacock | Fanny Crill |
| 2010 | Who Do You Think You Are? | Self |
| 2009 | The Lovely Bones | Grandma Lynn |
| 2009 | Leaves of Grass | Daisy Kincaid |
| 2009 | Solitary Man | Nancy Kalmen |
| 2009 | The Greatest | Grace Brewer |
| 2009 | Late Night with Jimmy Fallon | Self |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2009 | The Jay Leno Show | Self |
| 2009 | Live from Studio Five | Self |
| 2009 | Hollywood contra Franco | Self - Actress |
| 2009 | PoliWood | Self |
| 2009 | Grizzly | Narrator (voice) |
| 2008 | Speed Racer | Mom Racer |
| 2008 | Middle of Nowhere | Rhonda Berry |
| 2008 | Emotional Arithmetic | Melanie Lansing Winters |
| 2008 | Pip's Predicament: A Pop-Up Adventure | Queen Narissa (voice) |
| 2007 | Enchanted | Queen Narissa |
| 2007 | In the Valley of Elah | Joan Deerfield |
| 2007 | Mr. Woodcock | Beverly Farley |
| 2007 | The Graham Norton Show | Self |
| 2007 | The Dame Edna Treatment | |
| 2006 | 30 Rock | Lynn Onkman |
| 2006 | Irresistible | Sophie Hartley |
| 2006 | Bernard and Doris | Doris Duke |
| 2006 | Stardust: The Bette Davis Story | Narrator (voice) |
| 2006 | Home | |
| 2006 | The Exonerated | Sunny Jacobs |
| 2006 | Secrets of the Code | Narrator (voice) |
| 2006 | Christa McAuliffe: Reach for the Stars | Narrator (voice) |
| 2005 | American Dad! | Mrs. Jasperterian (voice) |
| 2005 | Elizabethtown | Hollie Baylor |
| 2005 | Romance & Cigarettes | Kitty Kane |
| 2005 | Jiminy Glick in Lalawood | Susan Sarandon |
| 2005 | The Tyra Banks Show | |
| 2005 | The Reichen Show | Self - Guest |
| 2005 | The Peace! | Self |
| 2005 | Hi-Jinks | |
| 2004 | Shall We Dance? | Beverly Clark |
| 2004 | Alfie | Liz |
| 2004 | Noel | Rose Collins |
| 2004 | Rescue Me | Alicia Green |
| 2004 | Project Runway | Self - Guest Judge |
| 2004 | The Tony Danza Show | Self - Guest |
| 2004 | Kulturplatz | Self |
| 2003 | Chappelle's Show | |
| 2003 | Real Time with Bill Maher | Self |
| 2003 | Frank Herbert's Children of Dune | Princess Wensicia Corrino |
| 2003 | The Ellen DeGeneres Show | Self |
| 2003 | Thelma & Louise: The Last Journey | Self |
| 2003 | Ice Bound | Dr. Jerri Nielsen |
| 2003 | The Nazi Officer's Wife | Narrator (voice) |
| 2003 | Moonlight Mile: A Journey to Screen | Self / Jojo Floss |
| 2003 | The Education of Gore Vidal | Self |
| 2002 | Igby Goes Down | Mimi |
| 2002 | The Banger Sisters | Lavinia |
| 2002 | Moonlight Mile | Jojo Floss |
| 2002 | Bull Durham: Between the Lines | Self |
| 2001 | Cats & Dogs | Ivy (voice) |
| 2001 | The Concert for New York City | Self |
| 2001 | Ghosts of Attica | Narrator |
| 2001 | Rudyland | Narrator (voice) |
| 2000 | Malcolm in the Middle | Meg |
| 2000 | Rugrats in Paris: The Movie | Coco LaBouche (voice) |
| 2000 | Frank Herbert's Dune | |
| 2000 | Joe Gould's Secret | Alice Neel |
| 2000 | Dirty Pictures | Self |
| 2000 | Ljuset håller mig sällskap | Self |
| 2000 | This Is What Democracy Looks Like | Narrator (voice) |
| 1999 | Anywhere but Here | Adele August |
| 1999 | Cradle Will Rock | Margherita Sarfatti |
| 1999 | Earthly Possessions | Charlotte Emory |
| 1999 | The Late Late Show with Craig Kilborn | Self - Guest |
| 1999 | Independent Lens | |
| 1999 | Our Friend, Martin | Mrs. Clark (voice) |
| 1999 | Where Are They Now? | Self |
| 1999 | Behind the Music: The Rocky Horror Picture Show | Self |
| 1999 | Goodnight Moon & Other Sleepytime Tales | Narrator (voice) |
| 1998 | Stepmom | Jackie Harrison |
| 1998 | Twilight | Catherine Ames |
| 1998 | Illuminata | Celimene |
| 1997 | The View | Self - Guest |
| 1996 | James and the Giant Peach | Miss Spider (voice) |
| 1996 | The Daily Show | Self |
| 1996 | The Celluloid Closet | Self |
| 1996 | The Rosie O'Donnell Show | Self - Guest |
| 1995 | Dead Man Walking | Sister Helen Prejean |
| 1995 | MADtv | Self |
| 1995 | MADtv | Self - Special Guest |
| 1995 | The Rocky Horror Double Feature Video Show | Self |
| 1994 | Friends | Jessica Lockhart |
| 1994 | Little Women | Mrs. March |
| 1994 | The Client | Reggie Love |
| 1994 | Inside the Actors Studio | Self |
| 1994 | Safe Passage | Mag |
| 1994 | Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Bitsy |
| 1993 | Late Show with David Letterman | Self |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1993 | Wilderness: The Last Stand | Self - Narrator (voice) |
| 1992 | The Player | Susan Sarandon |
| 1992 | Lorenzo's Oil | Michaela Odone |
| 1992 | Light Sleeper | Ann |
| 1992 | Bob Roberts | Tawna Titan |
| 1991 | Thelma & Louise | Louise |
| 1990 | White Palace | Nora Baker |
| 1989 | தி சிம்ப்சன்ஸ் | Susan Sarandon (voice) |
| 1989 | தி சிம்ப்சன்ஸ் | Ballet Teacher (voice) |
| 1989 | The January Man | Christine Starkey |
| 1989 | A Dry White Season | Melanie Bruwer |
| 1988 | Bull Durham | Annie Savoy |
| 1988 | LIVE with Kelly and Mark | |
| 1988 | LIVE with Kelly and Mark | Self - Guest |
| 1988 | American Experience | Narrator (voice) |
| 1988 | POV | Self - Narrator |
| 1988 | Sweet Hearts Dance | Sandra "Sandy" Boon |
| 1987 | The Witches of Eastwick | Jane Spofford |
| 1986 | Women of Valor | Col. Margaret Ann Jessup |
| 1985 | Compromising Positions | Judith Singer |
| 1985 | A.D. | Livilla |
| 1985 | Mussolini and I | Edda Mussolini Ciano |
| 1985 | Mussolini: The Decline and Fall of Il Duce | Edda Mussolini Ciano |
| 1984 | The Buddy System | Emily |
| 1984 | Beauty and the Beast | Beauty |
| 1984 | Oxbridge Blues | Natalie Carlsen |
| 1983 | The Hunger | Sarah Roberts |
| 1983 | Reading Rainbow | Herself - Narrator (voice) |
| 1982 | Tempest | Aretha Tomalin |
| 1982 | Faerie Tale Theatre | Beauty |
| 1982 | Who Am I This Time? | Helene Shaw |
| 1980 | Atlantic City | Sally |
| 1980 | Loving Couples | Stephanie |
| 1979 | Something Short of Paradise | Madeline Ross |
| 1978 | Pretty Baby | Hattie |
| 1978 | King of the Gypsies | Rose |
| 1978 | The Great Smokey Roadblock | Ginny |
| 1977 | The Other Side of Midnight | Catherine Alexander Douglas |
| 1977 | Checkered Flag or Crash | C.C. Wainwright |
| 1976 | Dragonfly | Chloe |
| 1975 | The Rocky Horror Picture Show | Janet Weiss |
| 1975 | Saturday Night Live | Self - Cameo (uncredited) |
| 1975 | The Great Waldo Pepper | Mary Beth |
| 1974 | The Front Page | Peggy Grant |
| 1974 | NOVA | Narrator (voice) |
| 1974 | Lovin' Molly | Sarah |
| 1974 | F. Scott Fitzgerald and the Last of the Belles | Ailie Calhoun |
| 1973 | Calucci's Department | |
| 1973 | The Haunting of Rosalind | Dita |
| 1971 | La mortadella | Sally |
| 1971 | Great Performances | Patsy Johnson |
| 1971 | Great Performances | Eileen |
| 1971 | Fleur Bleue | Elizabeth Hawkins |
| 1970 | Joe | Melissa Compton |
| 1966 | Goldene Kamera Verleihung | Self |
| 1962 | The Tonight Show Starring Johnny Carson | Self |
| 1956 | Tony Awards | Self - Presenter |
| 1953 | The Oscars | Self |
| 1944 | Golden Globe Awards | Self - Nominee |
