| — | Top Secret: Inside the World's Most Secret Agencies | Narrator (voice) |
| — | Baby Puffins & Bunny | Johnny Puff |
| — | The Carnival at the End of Days | Satan |
| — | Day Drinker | |
| 2024 | Johnny Puff: Secret Mission | Johnny Puff (voice) |
| 2024 | Scab Vendor: The Life and Times of Jonathan Shaw | Self |
| 2023 | Jeanne du Barry | Louis XV |
| 2023 | Depp V Heard | Self |
| 2023 | Johnny Depp: The Love of the Bizarre | Self (archive footage) |
| 2022 | Savage X Fenty Show Vol. 4 | Self (uncredited) |
| 2022 | Winona Ryder: The Ghosts She Called | Self (archive footage) |
| 2022 | Depp Vs. Heard: Winners & Losers | Self |
| 2022 | Johnny ve Amber: Nasıl Başladı, Nasıl Bitti? | Self (archive footage) |
| 2022 | Tell Me Iggy | Self |
| 2022 | TMZ Presents Johnny vs. Amber: From Love to Hate | |
| 2022 | Depp vs Heard: The Verdict | Self (archive footage) |
| 2022 | Puffins Impossible | Johnny Puff (voice) |
| 2021 | kid 90 | Self (archive footage) |
| 2021 | Johnny vs Amber | Self (archive footage) |
| 2021 | Johnny Depp: King of Cult | Self (archive footage) |
| 2021 | I Am a Mutoid: A Glastonbury Hero | Self (Archive Footage) |
| 2021 | Kreka: Dreamcatcher | Self |
| 2020 | Minamata | W. Eugene Smith |
| 2020 | Crock of Gold: A Few Rounds with Shane MacGowan | Self (archive footage) |
| 2020 | Puffins – The Series | Johnny Puff (voice) |
| 2019 | Waiting for the Barbarians | Colonel Joll |
| 2018 | Fantastic Beasts: The Crimes of Grindelwald | Gellert Grindelwald |
| 2018 | The Professor | Richard Brown |
| 2018 | Sherlock Gnomes | Sherlock Gnomes (voice) |
| 2018 | City of Lies | Russell Poole |
| 2018 | London Fields | Chick Purchase |
| 2018 | Brothers in Arms | Self |
| 2018 | Hollywood Vampires Live at Hellfest 2018 | Self |
| 2017 | Pirates of the Caribbean: Dead Men Tell No Tales | Jack Sparrow |
| 2017 | Murder on the Orient Express | Edward Ratchett |
| 2017 | Julian Schnabel: A Private Portrait | Self (archive footage) |
| 2017 | The Black Ghiandola | Nuclear Med Tech |
| 2016 | Fantastic Beasts and Where to Find Them | Gellert Grindelwald |
| 2016 | Alice Through the Looking Glass | Mad Hatter |
| 2016 | Yoga Hosers | Guy Lapointe |
| 2016 | Donald Trump's The Art of the Deal: The Movie | Donald J. Trump |
| 2016 | David Blaine: Beyond Magic | Self |
| 2015 | Black Mass | James 'Whitey' Bulger |
| 2015 | Mortdecai | Charlie Mortdecai |
| 2015 | The Nightmare | Self (archive footage) |
| 2015 | Hollywood Vampires - Rock in Rio 2015 | Self - Guitars |
| 2015 | The 90s: Ten Years That Changed the World | Self (archive footage) |
| 2014 | Transcendence | Dr. Will Caster |
| 2014 | Into the Woods | Big Bad Wolf |
| 2014 | Tusk | Guy Lapointe |
| 2014 | Don Rickles: One Night Only | Self |
| 2013 | The Lone Ranger | Tonto |
| 2013 | Lucky Them | Matthew Smith |
| 2013 | Don't Say No Until I Finish Talking: The Story of Richard D. Zanuck | Self |
| 2012 | 21 Jump Street | Officer Tom Hanson (uncredited) |
| 2012 | Dark Shadows | Barnabas Collins |
| 2012 | West of Memphis | Self – WM3 Supporter |
| 2012 | Paradise Lost 3: Purgatory | Self |
| 2012 | Dark Shadows: The Collinses - Every Family Has Its Demons | Self |
| 2012 | Sunset Strip | Self |
| 2012 | For No Good Reason | Self |
| 2012 | Honest Trailers | Willy Wonka (archive footage) |
| 2012 | Radioman | Self |
| 2012 | Kusturica - Balkan's Bad Boy | Himself |
| 2012 | Close Up | Self (archive footage) |
| 2011 | Pirates of the Caribbean: On Stranger Tides | Jack Sparrow |
| 2011 | Rango | Rango / Lars (voice) |
| 2011 | Jack and Jill | Johnny Depp (uncredited) |
| 2011 | The Rum Diary | Paul Kemp |
| 2011 | Life's Too Short | Johnny Depp |
| 2011 | Pirates of the Caribbean: Tales of the Code: Wedlocked | Jack Sparrow (archive footage) |
| 2011 | Real Creatures of Dirt | Self / Rango / Lars |
| 2010 | Alice in Wonderland | The Mad Hatter |
| 2010 | The Tourist | Frank Tupelo |
| 2010 | When You're Strange | Narrator (voice) |
| 2010 | Never Sleep Again: The Elm Street Legacy | Self (archive footage) |
| 2010 | Alice in Wonderland: Finding Alice | Self |
| 2010 | Alice in Wonderland: The Mad Hatter | Self |
| 2009 | Public Enemies | John Dillinger |
| 2009 | The Imaginarium of Doctor Parnassus | Imaginarium Tony 1 |
| 2009 | SpongeBob vs. the Big One | Jack Kahuna Laguna (voice) |
| 2009 | Michael Mann: Making 'Public Enemies' | Self |
| 2009 | Ballybrando | Self (archive footage) |
| 2008 | Gonzo: The Life and Work of Dr. Hunter S. Thompson | Narrator (voice) |
| 2008 | Sweeney Todd: The Demon Barber of Fleet Street - Burton + Carter + Depp = Todd | Self |
| 2008 | Rock and a Hard Place: Another Night at the Agora | Self |
| 2007 | Pirates of the Caribbean: At World's End | Jack Sparrow |
| 2007 | Sweeney Todd: The Demon Barber of Fleet Street | Sweeney Todd |
| 2007 | The Graham Norton Show | Self |
| 2007 | Joe Strummer: The Future Is Unwritten | Self |
| 2007 | Brando | Self |
| 2007 | Brando: The Documentary | Self |
| 2007 | Voom Portraits | Self |
| 2006 | Pirates of the Caribbean: Dead Man's Chest | Jack Sparrow |
| 2006 | Deep Sea 3D | |
| 2006 | Buy the Ticket, Take the Ride | Self |
| 2006 | Gypsy Caravan: When the Road Bends | Self |
| 2006 | Inside the Two Worlds of 'The Corpse Bride' | Self (voice) (uncredited) |
| 2006 | According to Plan: The Making of 'Pirates of the Caribbean: Dead Man's Chest' | Self |
| 2005 | Charlie and the Chocolate Factory | Willy Wonka |
| 2005 | Corpse Bride | Victor Van Dort (voice) |
| 2005 | It Came from... Baltimore!! | Self |
| 2005 | Charlie and the Chocolate Factory: Becoming Oompa-Loompa | Willy Wonka |
| 2005 | Nos Bastidores de Hollywood | Self |
| 2004 | Secret Window | Mort Rainey |
| 2004 | Finding Neverland | Sir James Matthew Barrie |
| 2004 | The Libertine | Rochester |
| 2004 | Happily Ever After | L'inconnu |
| 2004 | On Air with Ryan Seacrest | Self |
| 2004 | The Buried Secret of M. Night Shyamalan | Self |
| 2004 | Ed Wood: Pie Plates Over Hollywood | Self (archive footage) |
| 2004 | Ed Wood: Making Bela | Self / Edward D. Wood Jr. (archive footage) |
| 2004 | Ed Wood: Let's Shoot This @#!% | Self |
| 2003 | Pirates of the Caribbean: The Curse of the Black Pearl | Jack Sparrow |
| 2003 | Once Upon a Time in Mexico | CIA Agent Jeffrey Sands |
| 2003 | Jimmy Kimmel Live! | |
| 2003 | Charlie: The Life and Art of Charles Chaplin | |
| 2003 | Breakfast with Hunter | Self |
| 2003 | An Epic At Sea: The Making of Pirates of the Caribbean: The Curse of the Black Pearl | Self |
| 2003 | Celebrities Uncensored | Self |
| 2003 | Hunter Goes to Hollywood | Self |
| 2002 | Lost in La Mancha | Self |
| 2002 | All the Love You Cannes! | Self |
| 2001 | Blow | George Jung |
| 2001 | From Hell | Fred Abberline |
| 2001 | A Tour of the Inferno: Revisiting 'Platoon' | Self |
| 2000 | Chocolat | Roux |
| 2000 | Before Night Falls | Bon Bon / Lieutenant Victor |
| 2000 | The Man Who Cried | Cesar |
| 2000 | Sleepy Hollow: Behind the Legend | Self |
| 1999 | Sleepy Hollow | Ichabod Crane |
| 1999 | Family Guy | Edward Scissorhands (voice) |
| 1999 | The Ninth Gate | Dean Corso |
| 1999 | SpongeBob SquarePants | Jack Kahuna Laguna (voice) |
| 1999 | The Astronaut's Wife | Commander Spencer Armacost |
| 1999 | L.A. Without a Map | Self / William Blake (uncredited) |
| 1999 | The Source | Jack Kerouac |
| 1999 | In Bad Taste | Self |
| 1999 | The Early Show | Self |
| 1999 | Rove | Self |
| 1998 | Fear and Loathing in Las Vegas | Raoul Duke |
| 1998 | Spotlight on Location: Fear and Loathing in Las Vegas | Self |
| 1997 | Donnie Brasco | Donnie Brasco / Joseph D. 'Joe' Pistone |
| 1997 | King of the Hill | Yogi Victor (voice) |
| 1997 | The Brave | Raphael |
| 1997 | Cannes Man | Self |
| 1996 | E! True Hollywood Story | |
| 1995 | Dead Man | William Blake |
| 1995 | Nick of Time | Gene Watson |
| 1995 | Help! War Child | Self |
| 1995 | Sinatra: 80 Years My Way | Self - Audience Member (uncredited) |
| 1994 | Ed Wood | Ed Wood |
| 1994 | Don Juan DeMarco | Don Juan DeMarco |
| 1994 | The Vicar of Dibley | Self |
| 1994 | Inside the Actors Studio | Self |
| 1994 | The Fast Show | Customer in suit store |
| 1993 | What's Eating Gilbert Grape | Gilbert Grape |
| 1993 | Benny & Joon | Sam |
| 1993 | Arizona Dream | Axel Blackmar |
| 1992 | The Tonight Show with Jay Leno | |
| 1992 | MTV Movie & TV Awards | Self / Presenter |
| 1991 | Freddy's Dead: The Final Nightmare | Guy on TV |
| 1991 | Into The Great Wide Open | Eddie Rebel |
| 1990 | Edward Scissorhands | Edward Scissorhands |
| 1990 | Cry-Baby | Cry-Baby |
| 1990 | The Making of Edward Scissorhands | Self |
| 1987 | 21 Jump Street | Tom Hanson |
| 1986 | Platoon | Gator Lerner |
| 1986 | Slow Burn | Donnie Fleischer |
| 1985 | Private Resort | Jack |
| 1985 | Lady Blue | Lionel Viland |
| 1984 | A Nightmare on Elm Street | Glen Lantz |
| 1984 | MTV Video Music Awards | Self |
| 1982 | Hotel | Rob Cameron |
| 1981 | Entertainment Tonight | Self |
| 1953 | The Oscars | Self |
