| 2024 | Argylle | Alfie |
| 2024 | The Garfield Movie | Vic (voice) |
| 2024 | Damaged | Dan Lawson |
| 2024 | Fight Night: The Million Dollar Heist | Frank Moten |
| 2024 | The Piano Lesson | Doaker Charles |
| 2022 | The Fix | Narrator (voice) |
| — | Head Games | |
| — | Afterburn | Valentine |
| 2024 | The Unholy Trinity | St. Christopher |
| — | The Beast | President |
| — | Last Meals | Walter |
| 2023 | The Marvels | Nick Fury |
| 2023 | Secret Invasion | Nick Fury |
| 2023 | The Kill Room | Gordon |
| 2023 | Marvel Studios Assembled: The Making of Secret Invasion | Self - 'Nick Fury' |
| 2022 | Myke poter, skarpe klør | Jimbo (voice) |
| 2022 | Spider-Man: All Roads Lead to No Way Home | Self (archive footage) |
| 2022 | The Last Days of Ptolemy Grey | Ptolemy Grey |
| 2022 | Is That Black Enough for You?!? | Self |
| 2022 | The Jennifer Hudson Show | |
| 2022 | JANET JACKSON. | Self |
| 2021 | What If...? | Nick Fury (voice) |
| 2021 | What If...? | Sir Fury (voice) |
| 2021 | Hitman's Wife's Bodyguard | Darius Kincaid |
| 2021 | Spiral: From the Book of Saw | Marcus Banks |
| 2021 | The Protégé | Moody |
| 2021 | Marvel Studios Legends | Nick Fury (archive footage) |
| 2021 | Amend: The Fight for America | Self |
| 2021 | An Audience with Adele | Self |
| 2021 | Marvel Studios' 2021 Disney+ Day Special | Nick Fury (archive footage) |
| 2021 | Quentin Tarantino: From a Movie Buff to a Hollywood Legend | Video footage |
| 2021 | 2021 Rock & Roll Hall of Fame Induction Ceremony | Self |
| 2020 | The Banker | Joe Morris |
| 2020 | Death to 2020 | Dash Bracket |
| 2020 | The Last Full Measure | Takoda |
| 2020 | Staged | Sam |
| 2020 | #UNFIT: The Psychology of Donald Trump | Self (archive footage) |
| 2020 | One World: Together at Home | Self |
| 2020 | A West Wing Special to Benefit When We All Vote | Self |
| 2020 | Some Good News | Voice Over |
| 2020 | Enslaved | Self |
| 2020 | QUENTIN TARANTINO. How did he KILL BILL, shoot Hitler, and fight against Disney? | Video footage |
| 2020 | QUENTIN TARANTINO. How did he KILL BILL, shoot Hitler, and fight against Disney? | Video footage |
| 2020 | Enslaved with Samuel L Jackson | Presenter |
| 2020 | Beyond the Spotlight | |
| 2019 | Avengers: Endgame | Nick Fury |
| 2019 | Captain Marvel | Nick Fury |
| 2019 | Spider-Man: Far From Home | Nick Fury |
| 2019 | Star Wars: The Rise of Skywalker | Mace Windu (voice) |
| 2019 | Glass | Elijah Price / Mr. Glass |
| 2019 | Shaft | John Shaft |
| 2019 | QT8: The First Eight | Self (uncredited) |
| 2019 | The Movies That Made Us | Self (archive footage) |
| 2019 | Tamron Hall | Self - Guest |
| 2018 | Avengers: Infinity War | Nick Fury (uncredited) |
| 2018 | Incredibles 2 | Lucius Best / Frozone (voice) |
| 2018 | Life Itself | Self |
| 2018 | Quincy | Self |
| 2017 | Kong: Skull Island | Lieutenant Colonel Preston Packard |
| 2017 | xXx: Return of Xander Cage | Agent Augustus Gibbons |
| 2017 | The Hitman's Bodyguard | Darius Kincaid |
| 2017 | Unicorn Store | The Salesman |
| 2017 | I Am Not Your Negro | Narrator (voice) |
| 2017 | Carpool Karaoke: The Series | Self |
| 2017 | The Words That Built America | Self - Reader - Declaration of Independence |
| 2017 | John Travolta, le miraculé d'Hollywood | Self - Actor (archive footage) |
| 2017 | Creating a King: Summoning a God | Self |
| 2017 | Smokey Robinson: The Library of Congress Gershwin Prize for Popular Song | Host |
| 2016 | Miss Peregrine's Home for Peculiar Children | Barron |
| 2016 | The Legend of Tarzan | George Washington Williams |
| 2016 | Cell | Thomas 'Tom' McCourt |
| 2016 | Eating You Alive | Self |
| 2016 | BET Presents Love & Happiness: An Obama Celebration | Self |
| 2015 | Avengers: Age of Ultron | Nick Fury |
| 2015 | Kingsman: The Secret Service | Valentine |
| 2015 | The Hateful Eight | Major Marquis Warren |
| 2015 | Big Game | US President William Alan Moore |
| 2015 | Barely Lethal | Hardman |
| 2015 | The Late Show with Stephen Colbert | Self |
| 2015 | The Late Show with Stephen Colbert | |
| 2015 | Chi-Raq | Dolmedes |
| 2015 | Close Up with The Hollywood Reporter | Self |
| 2015 | Star Wars: Evolution of the Lightsaber Duel | Self |
| 2015 | Kingsman: The Secret Service Revealed | Self |
| 2015 | The Blackened Mantle | Mace Windu |
| 2014 | Captain America: The Winter Soldier | Nick Fury |
| 2014 | RoboCop | Pat Novak |
| 2014 | Reasonable Doubt | Clinton Davis |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | The Tonight Show Starring Jimmy Fallon | |
| 2014 | Kite | Lieutenant Karl Aker |
| 2014 | Marvel Studios: Assembling a Universe | Self |
| 2014 | Variety Studio: Actors on Actors | Self |
| 2014 | Life's Essentials with Ruby Dee | Self |
| 2014 | Face of Unity | Self |
| 2013 | Marvel's Agents of S.H.I.E.L.D. | Nick Fury |
| 2013 | Turbo | Whiplash (voice) |
| 2013 | Oldboy | Chaney |
| 2013 | Circus Halligalli | |
| 2013 | Everything Is Samuel L. Jackson's Fault | Self |
| 2012 | The Avengers | Nick Fury |
| 2012 | Django Unchained | Stephen |
| 2012 | Zambezia | Tendai (voice) |
| 2012 | Meeting Evil | Richie |
| 2012 | The Samaritan | Foley |
| 2012 | Final Cut: Hölgyeim és uraim | (archive footage) |
| 2012 | The Avengers: A Visual Journey | Self |
| 2012 | Honest Trailers | Mace Windu (archive footage) |
| 2012 | Honest Trailers | Nick Fury (archive footage) |
| 2012 | Quentin Tarantino: 20 Years of Filmmaking | Self |
| 2012 | Finding Your Roots | Self |
| 2012 | I Ain't Scared of You: A Tribute to Bernie Mac | Self |
| 2012 | Eddie Murphy: One Night Only | Self |
| 2011 | Captain America: The First Avenger | Nick Fury |
| 2011 | Thor | Nick Fury (uncredited) |
| 2011 | Kill Bill: The Whole Bloody Affair | Rufus |
| 2011 | Return to Jurassic Park | Self |
| 2011 | The Sunset Limited | Black |
| 2011 | Arena | Logan |
| 2011 | African Cats | Narrator (voice) |
| 2011 | Prohibition | Reader (voice) |
| 2011 | Dynamo: Magician Impossible | Self |
| 2011 | Under the Boardwalk: The Monopoly Story | Elmo McElroy (archive footage) |
| 2011 | The Jonathan Ross Show | Self |
| 2011 | Young Jeezy: A Hustlerz Ambition | Narrator |
| 2011 | On the Shoulders of Giants | |
| 2011 | Go the F**k to Sleep | Narrator (voice) |
| 2010 | Iron Man 2 | Nick Fury |
| 2010 | The Other Guys | P.K. Highsmith |
| 2010 | Unthinkable | Henry Harold 'H' Humphries |
| 2010 | With Great Power: The Stan Lee Story | Self |
| 2010 | Quantum Quest: A Cassini Space Odyssey | Fear (voice) |
| 2010 | Heavy Rain | |
| 2010 | In the Land of the Free... | Narrator |
| 2009 | Inglourious Basterds | Narrator (voice) (uncredited) |
| 2009 | Astro Boy | Zog (voice) |
| 2009 | Afro Samurai: Resurrection | Afro / Ninja-Ninja (voice) |
| 2009 | Mother and Child | Paul |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2009 | Alan Carr: Chatty Man | Self |
| 2009 | Uneven Fairways | Narrator |
| 2009 | The Face Is Familiar | Himself |
| 2008 | Iron Man | Nick Fury (uncredited) |
| 2008 | Jumper | Roland |
| 2008 | Star Wars: The Clone Wars | Mace Windu (voice) (archive sound) |
| 2008 | Star Wars: The Clone Wars | Mace Windu (voice) |
| 2008 | Lakeview Terrace | Abel Turner |
| 2008 | The Spirit | Octopus |
| 2008 | Soul Men | Louis Hinds |
| 2008 | The War | Narrator |
| 2008 | Gospel Hill | Paul Malcolm |
| 2008 | Crítico | Self |
| 2007 | 1408 | Gerald Olin |
| 2007 | Cleaner | Tom Cutler |
| 2007 | Afro Samurai | Afro Samurai / Ninja Ninja (voice) |
| 2007 | The Graham Norton Show | Self |
| 2007 | Resurrecting the Champ | Champ |
| 2007 | Respect Yourself: The Stax Records Story | Narrator |
| 2006 | Snakes on a Plane | Neville Flynn |
| 2006 | Black Snake Moan | Lazarus |
| 2006 | Freedomland | Lorenzo Council |
| 2006 | Home of the Brave | William Marsh |
| 2006 | Farce of the Penguins | Narrator (voice) |
| 2006 | O Código Tarantino | Jules Winnfield / Rufus (archive footage) |
| 2006 | The N Word | Himself |
| 2006 | The Henry Rollins Show | |
| 2006 | 50 Films to See Before You Die | Self |
| 2006 | Mais Bastidores de Hollywood | Self |
| 2006 | Honor Deferred | Narrator |
| 2005 | Star Wars: Episode III - Revenge of the Sith | Mace Windu |
| 2005 | Coach Carter | Ken Carter |
| 2005 | xXx: State of the Union | Agent Augustus Gibbons |
| 2005 | The Man | Derrick Vann |
| 2005 | Extras | Samuel L. Jackson |
| 2005 | The Boondocks | |
| 2005 | The Colbert Report | |
| 2005 | The Late Late Show with Craig Ferguson | An Officer of the Law |
| 2005 | The Late Late Show with Craig Ferguson | Self |
| 2005 | My Date with Drew | Self (uncredited) |
| 2005 | Mr. Incredible and Pals | Frozone (commentary voice) |
| 2005 | The Harlem Globetrotters: The Team That Changed the World | Self |
| 2005 | Coach Carter The Man Behind the Movie | Self |
| 2005 | Iconoclasts | Self |
| 2005 | George Lucas: Creating an Empire | Presenter/Self |
| 2005 | Unforgivable Blackness: The Rise and Fall of Jack Johnson | |
| 2004 | The Incredibles | Lucius Best / Frozone (voice) |
| 2004 | Kill Bill: Vol. 2 | Rufus |
| 2004 | Twisted | John Mills |
| 2004 | In My Country | Langston Whitfield |
| 2004 | Unforgivable Blackness: The Rise and Fall of Jack Johnson | Jack Johnson (voice) |
| 2004 | John Travolta: The Inside Story | Self |
| 2004 | Grand Theft Auto: San Andreas - The Introduction | Officer Frank Tenpenny (voice) (uncredited) |
| 2004 | Hollywood Legenden | Self |
| 2004 | America Beyond the Color Line | Self |
| 2003 | S.W.A.T. | Sgt. Dan 'Hondo' Harrelson |
| 2003 | Basic | West |
| 2003 | Real Time with Bill Maher | Himself |
| 2003 | The Ellen DeGeneres Show | Self |
| 2003 | Jimmy Kimmel Live! | |
| 2003 | Jimmy Kimmel Live! | Self |
| 2003 | Unchained Memories: Readings from the Slave Narratives | |
| 2002 | Star Wars: Episode II - Attack of the Clones | Mace Windu |
| 2002 | xXx | Agent Augustus Gibbons |
| 2002 | Changing Lanes | Doyle Gipson |
| 2002 | No Good Deed | Jack Friar |
| 2002 | BaadAsssss Cinema | Self |
| 2002 | Jackie Brown: How It Went Down | Self |
| 2002 | The Art of Action: Martial Arts in the Movies | Self - Narrator |
| 2002 | Middle School Confessions | Host |
| 2001 | The 51st State | Elmo McElroy |
| 2001 | The Proud Family | Joseph (voice) |
| 2001 | The Caveman's Valentine | Romulus |
| 2001 | R2-D2: Beneath the Dome | Self |
| 2001 | The 100 Greatest Films | Self |
| 2001 | Comic Books & Superheroes | Self |
| 2000 | Unbreakable | Elijah Price |
| 2000 | Shaft | John Shaft |
| 2000 | Rules of Engagement | Col. Terry L. Childers |
| 2000 | Any Given Wednesday | Willie Nutter |
| 2000 | Shaft: Still the Man | Self |
| 1999 | Star Wars: Episode I - The Phantom Menace | Mace Windu |
| 1999 | Deep Blue Sea | Russell Franklin |
| 1999 | Our Friend, Martin | Turner (voice) |
| 1999 | From Star Wars to Star Wars: The Story of Industrial Light & Magic | Narrator, Host |
| 1999 | The Early Show | Self |
| 1999 | Forever Hollywood | Self |
| 1998 | The Negotiator | Lt. Danny Roman |
| 1998 | Sphere | Dr. Harry Adams |
| 1998 | Out of Sight | Hejira Henry (uncredited) |
| 1998 | Le Violon rouge | Charles Morritz (Montréal) |
| 1998 | TRL | |
| 1998 | AFI's 100 Years... 100 Movies | Self |
| 1998 | Off the Menu: The Last Days of Chasen's | Self |
| 1997 | Jackie Brown | Ordell Robbie |
| 1997 | Hard Eight | Jimmy |
| 1997 | One Eight Seven | Trevor Garfield |
| 1997 | Eve's Bayou | Louis Batiste |
| 1997 | The View | Self |
| 1997 | The View | Self - Guest |
| 1997 | Leute heute | Self |
| 1996 | A Time to Kill | Carl Lee Hailey |
| 1996 | The Long Kiss Goodnight | Mitch Henessey |
| 1996 | The Daily Show | Self |
| 1996 | Trees Lounge | Wendell |
| 1996 | The Great White Hype | Rev. Fred Sultan |
| 1996 | Shaquille O'Neal: Larger than Life | Narrator (voice) |
| 1996 | The Journey of the African-American Athlete | Narrator |
| 1995 | Die Hard: With a Vengeance | Zeus Carver |
| 1995 | Kiss of Death | Calvin Hart |
| 1995 | Fluke | Rumbo (voice) |
| 1995 | Losing Isaiah | Kadar Lewis |
| 1995 | Happily Ever After: Fairy Tales for Every Child | The Mayor (voice) |
| 1995 | The Frank Skinner Show | Self |
| 1995 | A Night to Die For | Self - Host |
| 1994 | Pulp Fiction | Jules Winnfield |
| 1994 | Fresh | Sam |
| 1994 | Against the Wall | Jamaal |
| 1994 | Inside the Actors Studio | Self |
| 1994 | The Search for One-eye Jimmy | Colonel Ron |
| 1994 | The New Age | Dale Deveaux |
| 1994 | Hail Caesar | Mailman |
| 1994 | Assault at West Point: The Court-Martial of Johnson Whittaker | Richard Greener |
| 1993 | Jurassic Park | Arnold |
| 1993 | True Romance | Big Don |
| 1993 | Menace II Society | Tat Lawson |
| 1993 | National Lampoon's Loaded Weapon 1 | Wes Luger |
| 1993 | WWE Raw | |
| 1993 | Amos & Andrew | Andrew Sterling |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1992 | Patriot Games | Lt. Cmdr. Robby Jackson |
| 1992 | Juice | Trip |
| 1992 | White Sands | Greg Meeker |
| 1992 | The Tonight Show with Jay Leno | |
| 1992 | Fathers & Sons | Marshall |
| 1992 | Ghostwriter | Reggie Jenkins |
| 1992 | MTV Movie & TV Awards | Self - Presenter |
| 1992 | HBO First Look | |
| 1991 | Jungle Fever | Gator Purify |
| 1991 | Johnny Suede | B-Bop |
| 1991 | Strictly Business | Monroe |
| 1991 | Jumpin' at the Boneyard | Mr. Simpson |
| 1991 | Dead and Alive: The Race for Gus Farace | Everett Hatcher |
| 1990 | Mafiabrødre | Stacks Edwards |
| 1990 | The Exorcist III | Dream Blind Man (uncredited) |
| 1990 | Law & Order | Attorney Louis Taggert |
| 1990 | Mo' Better Blues | Madlock |
| 1990 | A Shock to the System | Ulysses |
| 1990 | Def by Temptation | Minister Garth |
| 1990 | Betsy's Wedding | Taxi Dispatcher (Mickey) |
| 1990 | The Return of Superfly | Nate Cabot |
| 1990 | Common Ground | Rev. Bob McClair |
| 1990 | Spike Lee & Company: Do It a Cappella | The Janitor |
| 1989 | Do the Right Thing | Mister Señor Love Daddy |
| 1989 | Sea of Love | Black Guy |
| 1989 | Making 'Do the Right Thing' | Self |
| 1989 | Dead Man Out | Calvin Fredricks |
| 1988 | Amerika for mine føtter | Hold-Up Man |
| 1988 | School Daze | Leeds |
| 1988 | LIVE with Kelly and Mark | |
| 1987 | Eddie Murphy Raw | Eddie's Uncle |
| 1987 | Uncle Tom's Cabin | George |
| 1987 | The Days and Nights of Molly Dodd | Brother Elvis |
| 1987 | Magic Sticks | Bum |
| 1985 | Spenser: For Hire | |
| 1981 | Ragtime | Gang Member No. 2 |
| 1980 | The Exterminator | Extra (uncredited) |
| 1978 | The Trial of the Moke | Johnson Whittaker |
| 1977 | The Displaced Person | Sulk |
| 1975 | Saturday Night Live | Self - Host |
| 1975 | Saturday Night Live | Self - Cameo (uncredited) |
| 1972 | Together for Days | Stan |
| 1971 | Great Performances | Self |
| 1956 | Tony Awards | Self - Presenter |
| 1953 | The Oscars | Self |
| 1952 | Today | Self |
| 1948 | Bambi-Verleihung | Self |
