| 2024 | Black Flies | Chief Burroughs |
| 2024 | In the Know | Self |
| 2024 | Bunny-Man | Bunny-Man |
| 2024 | Jake Paul vs. Mike Tyson | Self |
| 2024 | Battle of the Baddest | Self |
| 2023 | Medellin | Robbie |
| 2023 | L'Envers du sport : Jake Paul, l'enfant terrible de la boxe | Self |
| 2023 | Dear Mama | Self |
| 2023 | Once Within a Time | The Mentor |
| 2022 | Vendetta | Roach |
| 2022 | లైగర్ | Mark Anderson |
| 2022 | Woooooo! Becoming Ric Flair | Self |
| 2021 | Crack : Cocaïne, corruption et conspiration | Self (archive footage) |
| 2021 | L'Envers du sport : Une boxeuse en enfer | Self - Heavyweight Boxer |
| 2021 | The Making of Rocky vs. Drago by Sylvester Stallone | Self (archive footage) |
| 2021 | You're Watching Video Music Box | Self |
| 2021 | Hart to Heart | Self |
| 2021 | Once Upon a Time in Queens | Self |
| 2020 | AEW Double or Nothing | |
| 2020 | Reality Queen! | Mike Tyson |
| 2020 | Lennox Lewis: The Untold Story | Self |
| 2019 | Madea : Funérailles en famille | Roy |
| 2019 | All Elite Wrestling: Dynamite | Mike Tyson |
| 2019 | Desert Strike | ريك |
| 2019 | I Am Durán | Himself |
| 2018 | Kickboxer : L'Héritage | Briggs |
| 2018 | The Last O.G. | Triple O.G. |
| 2018 | Public Disturbance | Barry Black |
| 2018 | 42 to 1 | |
| 2018 | 閨蜜2 | Dragon |
| 2018 | Kadyrov, Ubu dictateur de Tchétchénie | Self |
| 2017 | Chris Brown: Welcome to My Life | Self |
| 2017 | Tour de Pharmacy | Mike Tyson |
| 2017 | Whitney : Can I Be Me | Himself (Archive Footage) (uncredited) |
| 2017 | China Salesman | Kabbah |
| 2016 | La Famille Black à Beverly Hills | James Clown |
| 2016 | Le Combat final | Mike |
| 2016 | Emigratis | |
| 2016 | To Tell the Truth | Self - Panelist |
| 2016 | Nine Legends | Self |
| 2015 | Ip Man 3 | Frank |
| 2015 | Entourage | Mike Tyson |
| 2015 | Lip Sync Battle | Self |
| 2015 | Champs | Self |
| 2015 | Brand: A Second Coming | Self |
| 2015 | Chasing Tyson | Self |
| 2015 | L'histoire de l'ascension du champion du monde de boxe invaincu Joe Calzaghe. | Himself |
| 2015 | Les Portes du soleil : Algérie pour toujours | Mike Tyson |
| 2015 | The Making of Trump | Self |
| 2014 | Le Tonight Show | |
| 2014 | I Am Ali | Self |
| 2014 | Mike Tyson Mysteries | Mike Tyson (voice) |
| 2013 | Scary Movie 5 | Mike Tyson |
| 2013 | Match Retour | Mike Tyson |
| 2013 | Mike Tyson: La vérité incontestée | Self |
| 2013 | No Más | |
| 2013 | Norm Macdonald Live | Self |
| 2013 | Wolfpack Only: The Hangover Retrospective | Self |
| 2013 | LT: The Life & Times | Self |
| 2013 | Being Mike Tyson | Self |
| 2012 | WWE: The Attitude Era | Mike "The Baddest Man On The Planet" Tyson |
| 2012 | WWE Hall Of Fame 2012 | |
| 2012 | Yo! The Story of ‘Yo! MTV Raps’ | Self |
| 2011 | Very Bad Trip 2 | Mike Tyson |
| 2011 | Comedy Central Roast of Charlie Sheen | Himself - Roaster |
| 2011 | Franklin & Bash | |
| 2011 | Breaking In | Himself |
| 2011 | Stone Cold Steve Austin: The Bottom Line on the Most Popular Superstar of All Time | Self (archive footage) |
| 2011 | When Harry Met Sally 2 with Billy Crystal and Helen Mirren | State Trooper |
| 2011 | The Cookout 2 | Fat Burger Griller |
| 2011 | Taking on Tyson | |
| 2010 | Conan | Self |
| 2010 | One Night in Vegas | Self |
| 2010 | Tyson: Unleashed | Himself |
| 2009 | Very Bad Trip | Mike Tyson |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2009 | Jason Marriner Football Hooligan | Self |
| 2008 | Tyson | Self |
| 2007 | Fool N Final | Mike Tyson |
| 2007 | WWE: The Best of Raw 15th Anniversary | Himself |
| 2006 | Rocky Balboa | Mike Tyson |
| 2006 | ESPN Classic Ringside: Mike Tyson | Mike Tyson |
| 2006 | Mike Tyson vs Corey Sanders | Self |
| 2005 | How I Met Your Mother | Mike Tyson |
| 2005 | Hell's Kitchen | Self - Restaurant Patron |
| 2005 | The Colbert Report | |
| 2005 | Attack of the Show! | Tyson (archive footage) (uncredited) |
| 2005 | The Outsider | Self |
| 2005 | Mike Tyson vs. McBride | Himself |
| 2004 | The Celebrity Apprentice | Tyson (archive footage) |
| 2004 | Quand m'aimera-t-on ? | Mike Tyson |
| 2004 | Planet Max 19 | Self |
| 2004 | Mike Tyson vs. Danny Williams | Himself |
| 2003 | Jimmy Kimmel Live! | |
| 2003 | High Chaparall | |
| 2003 | 2PAC 4Ever | Himself |
| 2003 | Comedy Central Roasts | Self |
| 2002 | Bolivia | Mike Tyson (archive footage) |
| 2001 | Crocodile Dundee III | Mike |
| 2000 | Mike Tyson vs. Lou Savarese | Himself |
| 2000 | Mike Tyson vs Julius Francis | Himself |
| 1999 | New York Unité Spéciale | Reggie Rhodes |
| 1999 | Les Adversaires | Mike Tyson |
| 1999 | Black and White | Mike Tyson |
| 1999 | Teen Choice Awards | Self |
| 1999 | Mike Tyson vs. Orlin Norris | Himself |
| 1998 | WWE Royal Rumble 1998 | "Iron" Mike Tyson (Appearance) |
| 1998 | WWE WrestleMania XIV | Mike Tyson (Ringside Enforcer) |
| 1996 | E! True Hollywood Story | |
| 1996 | Mike Tyson vs. Frank Bruno II | Self |
| 1993 | WWE Raw | |
| 1993 | WWE Raw | Self (archive footage) |
| 1993 | Fallen Champ: The Untold Story of Mike Tyson | Self (archive footage) |
| 1991 | The Record Breakers | Self (archive footage) |
| 1990 | Mike Tyson vs. Buster Douglas | Self |
| 1990 | Spike Lee Presents Mike Tyson | Themself |
| 1989 | Mike Tyson vs Frank Bruno | Self |
| 1988 | Shark Week | Self |
| 1988 | Mike Tyson vs. Michael Spinks | Himself |
| 1987 | Mike Tyson vs. Pinklon Thomas | |
| 1987 | Mike Tyson vs Tony Tucker | |
| 1986 | Mike Tyson vs Trevor Berbick | Self |
| 1986 | Mike Tyson vs David Jaco | |
| 1986 | Mike Jameson vs. Mike Tyson | |
| 1986 | Mike Tyson vs. Steve Zouski | |
| 1986 | James Tillis vs. Mike Tyson | |
| 1986 | Mike Tyson vs. Jesse Ferguson | |
| 1985 | Mike Tyson vs Ricardo Spain | |
| 1985 | Mike Tyson vs Robert Colay | |
| 1985 | Mike Tyson vs Sammy Scaff | |
| 1985 | Mike Tyson vs. Michael Johnson | |
| 1985 | Mike Tyson vs Don Halpin | |
| 1985 | Mike Tyson - Heavyweight Fights | Himself |
| 1982 | Mike Tyson vs Kelton Brown - US Junior Olympic Tournament | |
| — | Kickboxer : Armageddon | Briggs |
| — | Teofilo | Himself |
| 2023 | Stand | Self - Muslim (archive footage) |
| 2023 | Unstuffed: A Build-A-Bear Story | Self |
| 2021 | Bruno v Tyson | Self |
| 2021 | Biography: Shawn Michaels | Self - International Boxing & WWE Hall of Famer |
| 2021 | Meeting Stone Cold | Self |
| 2021 | Make It or Die Trying: The Frank Warren Story | Self |
| 2021 | Mike Tyson: The Knockout | |
| 2020 | Mike Tyson vs. Roy Jones Jr. | Self |
| 2020 | The Wait: Mike Tyson's First Fight Out of Prison | Boxer |
| 2019 | Sonny Liston - La vera storia | Self |
| 2019 | TYSON | Self |
| 2019 | One Night: Joshua vs. Ruiz | Self |
| 2017 | Superhuman | Self - Panelist |
| 2017 | OBJECTified | Self |
| 2016 | I Am JFK Jr. | Self |
| 2016 | Little Big Show | |
| 2013 | Sport in America: Our Defining Stories | Himself |
| 2012 | WWE Tagged Classics: Austin 3:16 Uncensored / Three Faces Of Foley / Chris Jericho: Break Down The Walls / Kurt Angle: Its True | Actor |
| 2006 | Bailando por un sueño | |
| 2003 | Mike Tyson vs Clifford Etienne | Self |
| 2002 | Kuba Wojewódzki | Self |
| 2002 | Lennox Lewis vs. Mike Tyson | Self |
| 2001 | Killer Instinct - The Rise and Fall of Mike Tyson | |
| 2001 | Mike Tyson vs Brian Nielsen | Himself |
| 2001 | Beyond the Glory | |
| 2000 | Mike Tyson vs Andrew Golota | Self |
| 1998 | The Mike Tyson Story | Himself |
| 1998 | Austin 3:16 Uncensored | Himself |
| 1997 | Mike Tyson vs. Evander Holyfield II | Himself |
| 1996 | Mike Tyson vs. Evander Holyfield I | Himself |
| 1996 | Mike Tyson vs Bruce Seldon | Self |
| 1995 | Kings of The Ring - History of Heavyweight Boxing 1919-1990 | Himself (Archival Footage) |
| 1995 | Mike Tyson vs Buster Mathis, Jr. | Self |
| 1991 | Voices That Care | Self - Choir Member |
| 1991 | Mike Tyson vs Donovan Razor Ruddock I | |
| 1991 | Mike Tyson vs Donovan Razor Ruddock II | |
| 1990 | Superstar: The Life and Times of Andy Warhol | Self (with wife Robin Givens) (archive footage) (uncredited) |
| 1990 | Mike Tyson vs. Alex Stewart | |
| 1989 | Mike Tyson vs Carl Williams | Self |
| 1989 | Great Sports Moments of the 80's | Self (archive footage) |
| 1988 | Yo! MTV Raps | Self |
| 1988 | Mike Tyson vs Larry Holmes | Self |
| 1986 | Mike Tyson vs. Alfonzo Ratliff | |
| 1986 | Mike Tyson vs Marvis Frazier | |
| 1985 | Mike Tyson vs. Hector Mercedes | |
| 1975 | Saturday Night Live | Self - Cameo (uncredited) |
