| — | Dexter: Original Sin | Harry Morgan |
| — | Last Call of a Dying Hawk | Jason Grey-Cameron |
| — | Guns III - Alias: Billy the Kid | Arkansas Dave Rudabaugh |
| 2024 | Sin edulcorar | Mike Diamond |
| 2024 | Parpadea dos veces | Vic Daymond |
| 2024 | Las crónicas de Spiderwick | Mulgarath / Dr. Dorian Brauer |
| 2023 | Freelance | Sebastian Earle |
| 2023 | Chupa | Richard Quinn |
| 2023 | Willow: así se hizo la magia | Self - 'Allagash' |
| 2022 | Willow | Allagash |
| 2022 | The Boys presenta: Diabolical | The Narrator (voice) |
| 2022 | Fleishman está en apuros | Archer Sylvan |
| 2022 | Winona Ryder - Die Geister, die sie rief | Christian Slater (archive footage) |
| 2021 | Ultrasecretos | Rand Ridley (voice) |
| 2021 | LEGO Star Wars Cuentos escalofriantes | Ren (voice) |
| 2021 | Dr. Death | Dr. Randall Kirby |
| 2020 | Superniños | Tech-No |
| 2019 | Scooby Doo y compañía | Christian Slater (voice) |
| 2019 | Tarantino total | Self (archive footage) |
| 2019 | La Biblioteca (The Public) | |
| 2019 | El programa de Kelly Clarkson | Self |
| 2018 | La buena esposa | Nathaniel Bone |
| 2018 | Escuadrón Suicida: Consecuencias infernales | Floyd Lawton / Deadshot (voice) |
| 2018 | En pocas palabras | Narrator (voice) |
| 2018 | Dirty John | Dan Broderick |
| 2018 | The Wolf: True Alpha | The Wolf |
| 2017 | La cordillera | Dereck McKinley |
| 2017 | The Lion Guard: The Rise of Scar | Ushari (voice) |
| 2017 | Heroes Manufactured | Self (archive footage) |
| 2017 | The Wolf | The Wolf |
| 2016 | King Cobra | Stephen (Bryan Kocis) |
| 2016 | Retales de una vida | Hans Reiser |
| 2016 | Justice League Action | Deadshot (voice) |
| 2015 | Mr. Robot | Mr. Robot |
| 2015 | Mr. Robot | Self - Mr. Robot |
| 2015 | Jacuzzi al pasado 2 | Choozy Doozy Host |
| 2015 | El amanecer de los Croods | Gurg (voice) |
| 2014 | Pregunta lo que quieras | Paul Spooner |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | Late Night with Seth Meyers | Self |
| 2014 | Way of the Wicked | Henry |
| 2014 | Stan Lee's Mighty 7 | Lazer Lord (voice) |
| 2014 | Mind Games | Ross Edwards |
| 2014 | Robot Chicken: Christmas Specials | Various (voice) (archive sound) |
| 2013 | Rick y Morty | Maximus Renegade Star Soldier (voice) |
| 2013 | Nymphomaniac. Volumen 1 | Joe's Father |
| 2013 | Nymphomaniac. Volumen 2 | Joe's Father |
| 2013 | Stranded | Col. Gerard Brauchman |
| 2013 | The Power of Few | Clyde |
| 2013 | Cisne blanco | Michael |
| 2012 | Una Bala En La Cabeza | Marcus Baptiste |
| 2012 | El Gringo | Lieutenant West |
| 2012 | Soldados de Fortuna | Craig Mackenzie |
| 2012 | Guns, Girls and Gambling | John Smith |
| 2012 | Playback | Frank Lyons |
| 2012 | El jinete del amanecer | John |
| 2012 | La bala del asesino | Robert |
| 2012 | Freaky Deaky | Skip Gibbs |
| 2012 | Rites of Passage | Delgado |
| 2012 | Hatfields and Mccoys: Bad Blood | Governor Bramlette |
| 2012 | Back To The Sea | Jack (voice) |
| 2011 | Los asesinatos del río | Agent Vuckovitch |
| 2011 | Breaking In | Oz |
| 2011 | Sacrifice | Father Porter |
| 2011 | ¿Y donde están los hombres? | Gordon |
| 2010 | Conan | Self |
| 2009 | Archer | Slater (voice) |
| 2009 | El cadillac de Dolan | Dolan |
| 2009 | Mentiras e ilusiones | Wes Wilson |
| 2009 | Sin identificar | Alex Donovan |
| 2008 | Igor | Dr. Schadenfreude's Igor (voice) |
| 2008 | Dinero sucio | Pollen |
| 2008 | Yo, Mi Peor Enemigo | Henry Spivey / Edward Albright |
| 2008 | Naked Movie | Self |
| 2007 | Parecía un hombre tranquilo | Bob Maconel |
| 2007 | Slipstream | Ray / Matt Dobbs / Patrolman #2 |
| 2007 | Los diez mandamientos | Moses (voice) |
| 2006 | Bobby | Daryl Timmons |
| 2006 | El hombre sin sombra 2 | Michael Griffin |
| 2006 | Crossing the Line | Narrator |
| 2005 | The Office | Christian Slater |
| 2005 | Me llamo Earl | Woody |
| 2005 | Alone in the Dark | Edward Carnby |
| 2005 | 8 Out of 10 Cats | Self |
| 2005 | El acuerdo | Tom Hanson |
| 2005 | The Friday Night Project | |
| 2005 | Robot Chicken's Christmas Special | Composite Santa Claus (voice) |
| 2004 | Cazadores de mentes | J.D. Reston |
| 2004 | Churchill: The Hollywood Years | Winston Churchill |
| 2004 | Secreto de confesión | Daniel Clemens |
| 2004 | Perseguido | Vincent Palmer |
| 2003 | Dos hombres y medio | Christian Slater |
| 2003 | Anónimos | Crew Guy #1 |
| 2003 | Dinosaur Planet | Narrator (voice) |
| 2003 | Jimmy Neutron: Operation: Rescue Jet Fusion | Jet Fusion (voice) |
| 2002 | Windtalkers | Sergeant Peter Henderson |
| 2002 | Jimmy Neutrón: el niño genio | Jet Fusion (voice) |
| 2002 | Top Gear | Star in a Reasonably-Priced Car |
| 2002 | Dinero sucio | Taylor |
| 2002 | Ant & Dec's Saturday Night Takeaway | Self |
| 2002 | Paul McCartney: Back in the U.S. | Self |
| 2001 | Zoolander (Un descerebrado de moda) | Christian Slater |
| 2001 | Los reyes del crimen | Hanson |
| 2001 | Alias | Neil Caplan |
| 2001 | ¿Quién es Cletis T...? | Trevor Allen Finch |
| 2001 | Friday Night with Jonathan Ross | Self - Guest |
| 2001 | Swatch Dogs and Diet Coke Heads | Self |
| 2000 | Larry David | Christian Slater |
| 2000 | Candidata al poder | Reginald Webster |
| 1999 | El ala oeste de la Casa Blanca | Lt. Cmdr. Jack Reese |
| 1998 | Hard Rain | Tom |
| 1998 | Very Bad Things | Robert Boyd |
| 1998 | Basil | John Mannion |
| 1998 | Saturday Night Live: The Best of Phil Hartman | Self |
| 1998 | Saturday Night Live: A Tribute to Chris Farley | Self |
| 1997 | Austin Powers: Misterioso agente internacional | Easily Fooled Security Guard (uncredited) |
| 1997 | The View | Self |
| 1997 | Las lágrimas de Julian Po | Julian Po |
| 1997 | Merry Christmas, George Bailey! | Harry Bailey / Sam Wainwright |
| 1996 | Broken Arrow: Alarma nuclear | Riley Hale |
| 1996 | The Daily Show | Self |
| 1996 | Mil ramos de rosas | Lewis Farrell |
| 1995 | Homicidio en primer grado | James Stamphill |
| 1995 | Die Harald Schmidt Show | Self - Guest |
| 1995 | Catwalk | Self |
| 1994 | Entrevista con el vampiro | Malloy |
| 1994 | Jimmy Hollywood | William |
| 1993 | Amor a quemarropa | Clarence Worley |
| 1993 | Corazón indomable | Adam |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1992 | FernGully. Las aventuras de Zak y Crysta | Pips (voice) |
| 1992 | Kuffs, poli por casualidad | George Kuffs |
| 1992 | The Tonight Show with Jay Leno | |
| 1992 | Donde te lleve el día (Where the Day Takes You) | Social Worker (uncredited) |
| 1992 | Shelley Duvall's Bedtime Stories | Narrator (Voice) |
| 1991 | Robin Hood, príncipe de los ladrones | Will Scarlett |
| 1991 | Star Trek VI: Aquel país desconocido | Excelsior Communications Officer |
| 1991 | El imperio del mal | Charlie "Lucky" Luciano |
| 1991 | Robin Hood: The Myth, the Man, the Movie | Self |
| 1990 | Intrépidos forajidos | Arkansas Dave Rudabaugh |
| 1990 | El gato infernal | Andy (segment ‘Lot 249’) |
| 1990 | Rebelión en las ondas | Mark Hunter |
| 1989 | Escuela de jóvenes asesinos | Jason 'J.D.' Dean |
| 1989 | El campeón del videojuego | Nick |
| 1989 | Al filo del abismo | Brian Kelly |
| 1989 | Mas allá de las estrellas | Eric Michaels |
| 1989 | Desperate for Love | Cliff Petrie |
| 1988 | Tucker, un hombre y su sueño | Junior |
| 1988 | LIVE with Kelly and Mark | |
| 1988 | This Morning | Self |
| 1987 | La rosa dei nomi | Self |
| 1987 | Going Live! | Self |
| 1986 | El nombre de la rosa | Adso of Melk |
| 1986 | La ley de Los Ángeles | Andy Prescott |
| 1986 | Crime Story | Teen Boy |
| 1986 | Alienado | Mark Collins |
| 1986 | Die Abtei des Verbrechens - Umberto Ecos „Der Name der Rose“ wird verfilmt | Self |
| 1985 | La leyenda de Billie Jean | Binx Davy |
| 1985 | The Equalizer | Michael Winslow |
| 1984 | Historias del más allá | Jody Tolliver |
| 1984 | Premios MTV Vídeos Musicales | Self - Host |
| 1983 | Living Proof: The Hank Williams Jr. Story | Walt Willey |
| 1981 | Sherlock Holmes: El Extraño Caso de Alice Faulkner | uncredited |
| 1977 | ABC Weekend Special | |
| 1975 | Saturday Night Live | Self - Host |
| 1975 | Saturday Night Live | Self - Cameo (uncredited) |
| 1962 | The Tonight Show Starring Johnny Carson | Self |
| 1953 | The Oscars | Self |
