| — | The Liar | Donald Trefusis |
| — | The Price of Admission | Alexander Taft |
| — | The Phoenician Scheme | |
| 2025 | Wicked Part Two | The Wizard |
| 2024 | KAOS | Zeus |
| 2024 | Wicked | The Wizard |
| 2024 | Defying Gravity: The Curtain Rises on Wicked | Self |
| 2023 | Asteroid City | The Alien |
| 2023 | They Shot the Piano Player | Jeff Harris (voice) |
| 2022 | Jurassic World Dominion | Ian Malcolm |
| 2022 | Jurassic Greatest Moments: Jurassic Park to Jurassic World | Self |
| 2022 | De Avondshow met Arjen Lubach | Self |
| 2022 | Fiddler's Journey to the Big Screen | Narrator |
| 2021 | What If...? | Grandmaster (voice) |
| 2021 | The Boss Baby: Family Business | Dr. Armstrong (voice) |
| 2021 | Beauty and the Beast: A Comic Relief Pantomime for Christmas | A Table |
| 2020 | Time Warp Vol. 1: Midnight Madness | Self |
| 2020 | Time Warp Vol. 2: Horror and Sci-Fi | Self |
| 2019 | The Kelly Clarkson Show | Self |
| 2019 | The Mountain | Dr. Wallace Fiennes |
| 2019 | The World According to Jeff Goldblum | Self |
| 2019 | Peanuts in Space: Secrets of Apollo 10 | Self |
| 2019 | #NoJoke | Self |
| 2019 | Jenny Lewis' On The Line Online | Self |
| 2018 | Jurassic World: Fallen Kingdom | Ian Malcolm |
| 2018 | Isle of Dogs | Duke (voice) |
| 2018 | Hotel Artemis | Orian "Wolf King" Franklin / Niagara |
| 2018 | Team Darryl | En Dwi Gast / Grandmaster |
| 2018 | Seth Rogen's Hilarity for Charity | Self |
| 2018 | James Cameron's Story of Science Fiction | Self |
| 2018 | Always at The Carlyle | Self |
| 2018 | A Place We Call Reality | Self (uncredited) |
| 2018 | Fallen Kingdom: Malcolm's Return | Self |
| 2018 | Fallen Kingdom: The Conversation | Self |
| 2017 | Guardians of the Galaxy Vol. 2 | En Dwi Gast / Grandmaster (uncredited) |
| 2017 | Thor: Ragnarok | Grandmaster |
| 2017 | Spielberg | Self |
| 2017 | Tour de Pharmacy | Marty Hass Present Day |
| 2017 | Broadway: The Next Generation | Self |
| 2017 | Miyubi | The Creator |
| 2016 | Independence Day: Resurgence | David Levinson |
| 2016 | Search Party | Tunnel |
| 2016 | Stephen Colbert's Live Election Night Democracy's Series Finale | Self |
| 2016 | Another Day: The Making of 'Independence Day: Resurgence' | Self |
| 2016 | Resurgence: It's Early Albuquerque | David Levinson |
| 2016 | The War of 1996: A United World News Special | David Levinson |
| 2015 | Mortdecai | Milton Krampf |
| 2015 | Unbreakable Kimmy Schmidt | Dr. Dave |
| 2015 | The Late Show with Stephen Colbert | Self |
| 2015 | The Late Show with Stephen Colbert | Self - Guest |
| 2015 | The Late Late Show with James Corden | Self |
| 2015 | The Late Late Show with James Corden | Self - Guest |
| 2015 | Hot Ones | Self |
| 2015 | Unity | Narrator (voice) |
| 2015 | StarTalk with Neil deGrasse Tyson | Self |
| 2014 | The Grand Budapest Hotel | Deputy Kovacs |
| 2014 | Last Week Tonight with John Oliver | Detective Zach Nichols |
| 2014 | The Tonight Show Starring Jimmy Fallon | Self |
| 2014 | Late Night with Seth Meyers | Self |
| 2013 | Le Week-End | Morgan |
| 2012 | Zambezia | Ajax (voice) |
| 2012 | Tim and Eric's Billion Dollar Movie | Chef Goldblum |
| 2012 | Finding Your Roots | Self |
| 2011 | Return to Jurassic Park | Self |
| 2011 | Portlandia | Vocal Coach |
| 2011 | Portlandia | The Pull-Out King |
| 2011 | Portlandia | The Doily Shoppe Proprietor |
| 2011 | Portlandia | Beet Accident Man |
| 2010 | The Switch | Leonard |
| 2010 | Morning Glory | Jerry Barnes |
| 2010 | Conan | Self |
| 2010 | Never Sleep Again: The Elm Street Legacy | Self (archive footage) |
| 2009 | Glee | Hiram Berry |
| 2009 | RuPaul's Drag Race | Self - Judge |
| 2009 | The League | Rupert Ruxin |
| 2009 | Late Night with Jimmy Fallon | Self |
| 2009 | Watch What Happens Live with Andy Cohen | Self - Guest |
| 2008 | Adam Resurrected | Adam Stein |
| 2008 | Easy to Assemble | |
| 2007 | The Graham Norton Show | Self |
| 2007 | The Graham Norton Show | Self - Guest |
| 2007 | Tim and Eric Awesome Show, Great Job! | Self |
| 2007 | Raines | Michael Raines |
| 2007 | Head Case | Self |
| 2007 | The Making of 'Fay Grim' or: How Do You Spell Espionage? | Himself |
| 2006 | Man of the Year | Stewart |
| 2006 | Mini's First Time | Mike Rudell |
| 2006 | Fay Grim | Agent Fulbright |
| 2006 | Pittsburgh | Self |
| 2005 | The Colbert Report | |
| 2005 | The Late Late Show with Craig Ferguson | Self |
| 2005 | Dallas 362 | Bob |
| 2005 | Matthew Gray Gubler's Life Aquatic Intern Journal | Self |
| 2005 | Fear of the Flesh: The Making of The Fly | Self |
| 2005 | On the Set: 'The Life Aquatic with Steve Zissou' | Self / Alistair |
| 2005 | This Is an Adventure | Self |
| 2005 | Movies That Shook the World | |
| 2004 | The Life Aquatic with Steve Zissou | Alistair Hennessey |
| 2004 | Incident at Loch Ness | Self - Party Guest |
| 2004 | Tom Goes to the Mayor | Bill Joel (voice) |
| 2004 | Stories of Lost Souls | Himself |
| 2004 | Hollywood's Creepiest Creatures | Self |
| 2003 | The Ellen DeGeneres Show | Self |
| 2003 | Jimmy Kimmel Live! | Self |
| 2003 | Jimmy Kimmel Live! | Self - Guest Host |
| 2003 | Spinning Boris | George Gorton |
| 2003 | War Stories | Ben Dansmore |
| 2003 | Abby Singer | Jeff Goldblum (uncredited) |
| 2003 | Supermarket | Self |
| 2003 | DNA | Narrator |
| 2002 | Top Gear | Star in a Reasonably-Priced Car |
| 2002 | Igby Goes Down | D.H. |
| 2002 | Run Ronnie Run | Self |
| 2002 | Ant & Dec's Saturday Night Takeaway | Self |
| 2002 | Saturday Night Live: The Best of Will Ferrell | Dr. Ken Waller (archive footage) |
| 2002 | Robbie the Reindeer: Legend of the Lost Tribe | White Rabbit (voice) |
| 2002 | One of the Hollywood Ten | Herbert Biberman |
| 2002 | Buckaroo Banzai Declassified | Self |
| 2001 | Cats & Dogs | Professor Brody |
| 2001 | Law & Order: Criminal Intent | Zach Nichols |
| 2001 | Chain of Fools | Avnet |
| 2001 | Perfume | Jamie |
| 2001 | Primetime Glick | |
| 2001 | Playboy Mansion Parties Uncensored | Self |
| 2001 | Festival in Cannes | Self (uncredited) |
| 2000 | Fantasia 2000 | Self - Host |
| 2000 | Auggie Rose | John Nolan |
| 1999 | The Prince of Egypt: From Dream to Screen | Self (archive footage) |
| 1999 | From Star Wars to Star Wars: The Story of Industrial Light & Magic | Self |
| 1999 | The Big Chill: A Reunion | Self |
| 1999 | When Dinosaurs Ruled | |
| 1998 | The Prince of Egypt | Aaron (voice) |
| 1998 | Will & Grace | Scott Woolley |
| 1998 | Holy Man | Ricky Hayman |
| 1998 | Welcome to Hollywood | Jeff Goldblum |
| 1998 | Roswell Top Secret | Self |
| 1997 | The Lost World: Jurassic Park | Ian Malcolm |
| 1997 | King of the Hill | Dr. Vayzosa (voice) |
| 1997 | The View | Self |
| 1997 | The Story of Bean | himself |
| 1997 | The Making of 'The Lost World' | Self |
| 1997 | Hollywood Dreamers | Self |
| 1997 | Nachtstudio | Self |
| 1996 | Independence Day | David Levinson |
| 1996 | The Great White Hype | Mitchell Kane |
| 1996 | Mad Dog Time | Mickey Holliday |
| 1996 | Independence Day: The ID4 Invasion | Self |
| 1996 | The Making of 'Independence Day' | Self - Host |
| 1995 | Powder | Donald Ripley |
| 1995 | Nine Months | Sean Fletcher |
| 1995 | Hideaway | Hatch Harrison |
| 1995 | Mr. Show with Bob and David | Civil War Narrator |
| 1995 | The Making of 'Jurassic Park' | Self / Ian Malcolm |
| 1995 | Die Harald Schmidt Show | Self |
| 1994 | Friends | Leonard Hayes |
| 1994 | Future Quest | Himself (Host) |
| 1993 | Jurassic Park | Malcolm |
| 1993 | Late Night with Conan O'Brien | Self - Guest |
| 1993 | GMTV | Self |
| 1993 | The Real Jurassic Park | Narrator |
| 1993 | Lush Life | Al gorky |
| 1992 | The Player | Jeff Goldblum |
| 1992 | Deep Cover | David Jason |
| 1992 | The Larry Sanders Show | Jeff Goldblum |
| 1992 | Fathers and Sons | Max |
| 1992 | Shooting Elizabeth | Howard Pigeon |
| 1992 | Robert Altman's Players | Self |
| 1992 | Terry Wogan's Friday Night | Self |
| 1991 | The Favor, the Watch and the Very Big Fish | Pianist |
| 1990 | Captain Planet and the Planeteers | Verminous Skumm (voice) |
| 1990 | Mister Frost | Mr. Frost |
| 1990 | Framed | Wiley |
| 1990 | Sing! Sesame Street Remembers Joe Raposo and His Music | Self |
| 1989 | The Simpsons | MacArthur Parker (voice) |
| 1989 | The Tall Guy | Dexter King |
| 1989 | Twisted Obsession | Daniel Gillis |
| 1988 | Earth Girls Are Easy | Mac |
| 1988 | Vibes | Nick Deezy |
| 1988 | LIVE with Kelly and Mark | |
| 1987 | Beyond Therapy | Bruce |
| 1987 | Life Story | Jim Watson |
| 1986 | The Fly | Seth Brundle |
| 1986 | Bugs Bunny/Looney Tunes All-Star 50th Anniversary | Self |
| 1986 | Long Live the New Flesh: The Films of David Cronenberg | Self (archive footage) |
| 1986 | The Town Where No One Got Off | Cogswell |
| 1985 | Silverado | Slick |
| 1985 | Into the Night | Ed Okin |
| 1985 | Transylvania 6-5000 | Jack Harrison |
| 1985 | The Ray Bradbury Theater | Cogswell |
| 1985 | B.B. King: Into the Night | Self |
| 1984 | The Adventures of Buckaroo Banzai Across the 8th Dimension | New Jersey |
| 1984 | Terror in the Aisles | Jack Bellicec (archive footage) (uncredited) |
| 1984 | Ernie Kovacs: Between the Laughter | Ernie Kovacs |
| 1983 | The Right Stuff | NASA Recruiter |
| 1983 | The Big Chill | Michael Gold |
| 1982 | Faerie Tale Theatre | Buck Wolf |
| 1982 | Rehearsal for Murder | Leo Gibbs |
| 1982 | American Playhouse | |
| 1982 | The Devlin Connection | |
| 1981 | Threshold | Dr. Aldo Gehring |
| 1980 | The Legend of Sleepy Hollow | Ichabod Crane |
| 1980 | Tenspeed and Brown Shoe | Lionel Whitney |
| 1978 | Invasion of the Body Snatchers | Jack Bellicec |
| 1978 | Thank God It's Friday | Toni Di Marco |
| 1978 | Remember My Name | Mr. Lee Nudd |
| 1977 | Annie Hall | Lacey Party Guest |
| 1977 | The Sentinel | Jack |
| 1977 | Between the Lines | Max |
| 1976 | Laverne & Shirley | |
| 1976 | St. Ives | Hood |
| 1976 | Next Stop, Greenwich Village | Clyde Baxter |
| 1976 | Special Delivery | Snake |
| 1975 | Saturday Night Live | Self - Host |
| 1975 | Nashville | Tricycle Man |
| 1975 | Starsky & Hutch | |
| 1974 | Death Wish | Freak #1 |
| 1974 | California Split | Lloyd Harris |
| 1971 | Columbo | Protester (uncredited) |
| 1968 | The Dick Cavett Show | Self - Guest |
| 1952 | Today | Self |
